Results 111 to 120 of about 761,097 (299)
Circular on Deployments, Secondments, Leave of Absence and Transfers in The Public Service [PDF]
Reference is made to the self-explanatory Circular Ref. PSC/ADM/13(60) dated 20th.February 2025 on the above subject (copy attached). In the above referenced Circular, the Public Service Commission (PSC) notes that there have been irregular deployments,
The National Treasury and Economic Planning
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma
, 2023 Hongliang Wu,1– 3 Sihang Zheng,4 Qun He,5 Yan Li3 1Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China; 2Department of Orthopedics, Fuzhou Second Hospital ...
Li Y, Zheng S, He Q, Wu H
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Circular on Registration and Management of Public Service Retirement Benefit Schemes [PDF]
On 24th November 2010, the National Treasury issued Treasury Circular No. 18/2010 to guide the registration and management of public service retirement benefits schemes and ensure equity in sharing the cost of funding scheme benefits between the employer
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Circular on Schedule of Submission of the 2023 Every Two-Year Declaration of Income. Assets and Liabilities Forms [PDF]
, 2023 Reference is made to Circular Ref. No.PSC/218/110/XII VOL.Vll/(19) dated 18th October, 2023 providing guidelines for receiving and processing of the 2023 every two year declarations of income assets and liabilities forms by organizations. In this regard,
The Public Service Commission
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Viroid-like RNAs from cherry: the first satellite RNAs of micoviruses?
, 2013 Several years ago, two cherry small circular RNAs (cscRNA1 and cscRNA2) and 10-12 double stranded RNAs (dsRNAs) of presumable viral origin were identified in sweet and sour cherry plants grown in Italy. These RNAs were found to be closely associated to a
Covelli L +8 more
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