Results 111 to 120 of about 2,013,218 (333)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction

, 2023
Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs.
Jimin Cao, Jialei Li, Shuang Wang, Xiaolei Wu, Yu Han, Teng Sun   +5 more
core   +1 more source

Circular RNAs: Promising Biomarkers for Human Diseases

EBioMedicine, 2018
Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as ...
Zhongrong Zhang, Tingting Yang, Junjie Xiao   +2 more
semanticscholar   +1 more source

Methods for analysis of circular RNAs [PDF]

WIREs RNA, 2019
AbstractEukaryotic cells express a myriad of circular RNAs (circRNAs), many of them displaying tissue‐specific expression patterns. They arise from linear precursor RNAs in which 5′ and 3′ ends become covalently ligated. Given these features, biochemical and computational approaches traditionally used to study linear RNA must be adapted for analysis of
Poonam R. Pandey, Rachel Munk, Gautam Kundu, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe   +5 more
openaire   +2 more sources

Sequence and structural properties of circular RNAs in the brain of nurse and forager honeybees (Apis mellifera)

BMC Genomics, 2019
Background The honeybee (Apis mellifera) represents a model organism for social insects displaying behavioral plasticity. This is reflected by an age-dependent task allocation. The most protruding tasks are performed by young nurse bees and older forager
Clemens Thölken, Markus Thamm, Christoph Erbacher, Marcus Lechner   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Genome-Wide Profiling of Circular RNAs in the Rapidly Growing Shoots of Moso Bamboo (Phyllostachys edulis). [PDF]

, 2019
Circular RNAs, including circular exonic RNAs (circRNA), circular intronic RNAs (ciRNA) and exon-intron circRNAs (EIciRNAs), are a new type of noncoding RNAs.
Kohnen, Markus V, Wang, Yongsheng, Zhang, Hangxiao, Hu, Kaiqiang, Gu, Lianfeng, Xi, Feihu, Liu, Xuqing, Zhao, Liangzhen, Xu, Xi, Wang, Huihui, Lin, Chentao, Wang, Huiyuan, Zhang, Zeyu, Gao, Yubang   +13 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex

Genome Biology, 2017
Background Circular RNAs are a class of endogenous RNAs with various functions in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently, nothing is known about their role in head and neck squamous cell carcinoma (HNSCC)
Lorena Verduci, Maria Ferraiuolo, Andrea Sacconi, Federica Ganci, Jlenia Vitale, Teresa Colombo, Paola Paci, Sabrina Strano, Giuseppe Macino, Nikolaus Rajewsky, Giovanni Blandino   +10 more
doaj   +1 more source

Circular RNA Expression Profiling Identifies Glaucoma-Related Circular RNAs in Various Chronic Ocular Hypertension Rat Models

Frontiers in Genetics, 2020
Circular RNAs are characterized as a class of covalently closed circular RNA transcripts and are associated with a variety of cellular processes and neurological diseases by sponging microRNAs.
Xiaoxiao Chen, Xiaoxiao Chen, Xiaoxiao Chen, Rongmei Zhou, Rongmei Zhou, Kun Shan, Kun Shan, Yanan Sun, Yanan Sun, Biao Yan, Biao Yan, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Jiajian Wang, Jiajian Wang, Jiajian Wang   +17 more
doaj   +1 more source