Results 91 to 100 of about 2,013,218 (333)
Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Signal Transduction and Targeted Therapy, 2021 Significant progress has been made in circular RNA (circRNA) research in recent years. Increasing evidence suggests that circRNAs play important roles in many cellular processes, and their dysregulation is implicated in the pathogenesis of various ...
Alina T. He +3 more
semanticscholar +1 more source
MedCommAbstractCircular RNA (circRNA), a subtype of noncoding RNA, has emerged as a significant focus in RNA research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles in diverse physiological and pathological processes, functioning through mechanisms such as miRNAs or proteins sponging, regulation of splicing and gene ...
Yang Guo +8 more
openaire +2 more sources
Mechanisms of circular RNA degradation
Communications Biology, 2022 In this Perspective, Longxin Ren and co-authors summarise the role of circular RNAs in disease and discuss recent insights into how circular RNAs are metabolised in the cell.
Longxin Ren +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nature Communications, 2016 Circular RNAs are formed from exon back-splicing, the significance of these endogenous RNAs is beginning to be unraveled. Here, the authors identify thousands of circular RNAs differentially expressed between normal and cancer tissues and show that an ...
Qiupeng Zheng +13 more
doaj +1 more source
Characterization of circular RNAs in dorsal root ganglia after central and peripheral axon injuries
Frontiers in Cellular Neuroscience, 2022 In central nervous system, axons fail to regenerate after injury while in peripheral nervous system, axons retain certain regenerative ability. Dorsal root ganglion (DRG) neuron has an ascending central axon branch and a descending peripheral axon branch
Hong-Jun Cao +4 more
doaj +1 more source
Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma
, 2023 Hongliang Wu,1– 3 Sihang Zheng,4 Qun He,5 Yan Li3 1Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China; 2Department of Orthopedics, Fuzhou Second Hospital ...
Li Y, Zheng S, He Q, Wu H
core
Circular RNAs in cancer: opportunities and challenges in the field
Oncogene, 2017 Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a steadily increasing pace.
L. Kristensen +3 more
semanticscholar +1 more source
Molecular Cancer, 2022 The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of therapeutic resistance may provide new strategies for overcoming cancer ...
Hong Lin +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source