Results 61 to 70 of about 761,097 (299)
Knockout of circRNAs by base editing back-splice sites of circularized exons
Genome Biology, 2022 Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs. Methods for circRNA-specific knockout are lacking, largely due to sequence overlaps between forms. Here, we
Xiang Gao +10 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
MedCommAbstractCircular RNA (circRNA), a subtype of noncoding RNA, has emerged as a significant focus in RNA research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles in diverse physiological and pathological processes, functioning through mechanisms such as miRNAs or proteins sponging, regulation of splicing and gene ...
Yang Guo +8 more
openaire +2 more sources
Circular on Development of the Medium-Term Revenue Strategy (MTRS) for FY 2023/2024-2026-2027
, 2022 The purpose of this Circular is to inform the Government Ministries, Departments and Agencies (MDAs) and the County Governments of the Government's intention to develop a Strategy to enhance revenue mobilization to facilitate implementation of Government
core
Circular on Guidelines for Preparation of the 2022/2023-2024/2025 Medium-Term Budget [PDF]
, 2021 1. This Circular is issued in accordance with Section 36 of the Public Finance ,, Management Aet,,2012 which requires the Cabinet Secretary/National Treasury and Planning to issue to all National Government entities a circular outlining the guidelines ...
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Characterization of circular RNAs in dorsal root ganglia after central and peripheral axon injuries
Frontiers in Cellular Neuroscience, 2022 In central nervous system, axons fail to regenerate after injury while in peripheral nervous system, axons retain certain regenerative ability. Dorsal root ganglion (DRG) neuron has an ascending central axon branch and a descending peripheral axon branch
Hong-Jun Cao +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Biogenesis and Regulatory Roles of Circular RNAs
, 2022 Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular housekeeping noncoding RNAs and precursor messenger RNAs.
Wilusz, Jeremy E +2 more
core +1 more source
Circular RNA in Diseased Heart
Cells, 2020 Heart disease remains the leading cause of death globally and leads to tremendous socio-economic burden. Despite advances in the field of cardiovascular research, novel theranostics are still in urgent need.
Ying Wang, Bin Liu
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source