Results 91 to 100 of about 6,604 (278)

Relating 2-Rainbow Domination To Roman Domination

Discussiones Mathematicae Graph Theory, 2017
For a graph G, let R(G) and yr2(G) denote the Roman domination number of G and the 2-rainbow domination number of G, respectively. It is known that yr2(G) ≤ R(G) ≤ 3/2yr2(G). Fujita and Furuya [Difference between 2-rainbow domination and Roman domination
Alvarado José D., Dantas Simone, Rautenbach Dieter   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Neo-republicanism as a route to animal non-domination [PDF]

, 2016
In this article, we reinterpret the current political turn in animal rights theory in terms of republican as opposed to liberal political theory. By appealing to the values of liberty and fraternity as well as equality, we argue for a conception of ...
Allen, Michael P., Von Essen, Erica
core  

Reduction of the Pareto Set in Bicriteria Asymmetric Traveling Salesman Problem

, 2018
We consider the bicriteria asymmetric traveling salesman problem (bi-ATSP). Optimal solution to a multicriteria problem is usually supposed to be the Pareto set, which is rather wide in real-world problems.
Kovalenko, Yulia V., Zakharov, Aleksey O.   +1 more
core   +1 more source

Non-domination and democratic legitimacy [PDF]

Critical Review of International Social and Political Philosophy, 2015
While many regard equality as the moral foundation of democracy, republican theory grounds democracy in freedom as non-domination. The grounding of democracy in freedom has been criticized for relying on either an Aristotelian perfectionism or a Rousseauian equation of the people in their collective capacity and the people understood severally.
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Cultural Diversity and Reasonable Accommodation. An Approach based on Freedom as Non-domination [PDF]

Entre los retos que afrontan las actuales sociedades culturalmente diversas se encuentra el de aprender a convivir en la diferencia. Uno de los mecanismos que se ensaya en los procesos de gestión de la diversidad cultural es el de las prácticas de ...
Wences, Isabel
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source