Results 161 to 170 of about 1,026 (217)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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A New Algorithm Using the Non-Dominated Tree to Improve Non-Dominated Sorting
Evolutionary Computation, 2018Non-dominated sorting is a technique often used in evolutionary algorithms to determine the quality of solutions in a population. The most common algorithm is the Fast Non-dominated Sort (FNS). This algorithm, however, has the drawback that its performance deteriorates when the population size grows.
Patrik Gustavsson, Anna Syberfeldt
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2022
Abstract Republicans maintain that people are not free when others dominate their choices, even when those others happen to be benevolent or indifferent. Both individual persons and proper group agents can dominate others, but teams can dominate only when the members of those teams have actually solved or are immanently poised to solve ...
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Abstract Republicans maintain that people are not free when others dominate their choices, even when those others happen to be benevolent or indifferent. Both individual persons and proper group agents can dominate others, but teams can dominate only when the members of those teams have actually solved or are immanently poised to solve ...
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University of Toronto Law Journal, 2012
My aim here is to defend a view of non-domination as providing a better basis for justice than the going alternatives. I differentiate it from two kinds of alternatives: those whose proponents reject my claim that non-domination is the bedrock of justice and those who agree with me but understand non-domination differently than I do.
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My aim here is to defend a view of non-domination as providing a better basis for justice than the going alternatives. I differentiate it from two kinds of alternatives: those whose proponents reject my claim that non-domination is the bedrock of justice and those who agree with me but understand non-domination differently than I do.
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2021
Abstract This chapter develops the fundamental features of liberal non-domination. It connects the expressive perspective (chapter 2) to a liberal framework for social justice, aiming at fair cooperation between free and equal individuals endowed with two moral powers—sense of justice and capacity for a conception of the good—and derives
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Abstract This chapter develops the fundamental features of liberal non-domination. It connects the expressive perspective (chapter 2) to a liberal framework for social justice, aiming at fair cooperation between free and equal individuals endowed with two moral powers—sense of justice and capacity for a conception of the good—and derives
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Edges of mutually non-dominating sets
Proceedings of the 15th annual conference on Genetic and evolutionary computation, 2013Multi-objective optimisation yields an estimated Pareto front of mutually non-dominating solutions, but with more than three objectives understanding the relationships between solutions is challenging. Natural solutions to use as landmarks are those lying near to the edges of the mutually non-dominating set.
Richard M. Everson +2 more
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The Insufficiency of Non-Domination
Political Theory, 2008This essay argues that the neo-Roman republican principle of “non-domination,” as developed in the recent work of Philip Pettit, cannot serve as a single over-arching political ideal, because it responds to only one of two important dimensions of concern about human agency.
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