Results 71 to 80 of about 11,194,247 (285)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

What is Racism?

open access: yesJournal of World-Systems Research, 2016
This article provides a definition of racism inspired in the work of Frantz Fanon, Boaventura de Sousa Santos and contemporary Caribbean Fanonian Philosophers. It discusses racism in relation to zone of being and zone of non-being. Racism is discussed as
Ramon Grosfoguel
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

La liberté républicaine et la démocratisation du régime international [PDF]

open access: yesLes Ateliers de l’Ethique, 2009
L’idéal républicain de la liberté comme non-domination promu par P. Pettit possède un potentiel intéressant pour penser l’évolution de l’internationalisme.
Dave Anctil
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Domination number of the non-commuting graph of finite groups

open access: yesElectronic Journal of Graph Theory and Applications, 2018
Let G be a non-abelian group. The non-commuting graph of group G, shown by ΓG, is a graph with the vertex set G \ Z(G), where Z(G) is the center of group G. Also two distinct vertices of a and b are adjacent whenever ab ≠ ba.
Ebrahim Vatandoost, Masoumeh Khalili
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Relating 2-Rainbow Domination To Roman Domination

open access: yesDiscussiones Mathematicae Graph Theory, 2017
For a graph G, let R(G) and yr2(G) denote the Roman domination number of G and the 2-rainbow domination number of G, respectively. It is known that yr2(G) ≤ R(G) ≤ 3/2yr2(G). Fujita and Furuya [Difference between 2-rainbow domination and Roman domination
Alvarado José D.   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Auch eine Politik der Nichtidentität

open access: yesTr@jectoires, 2020
Une politique de la non-identité est rarement perçue sous l’aspect du changement qu’implique la conception de la non-identité au concept de la politique.
Frank Müller
doaj   +1 more source

Home - About - Disclaimer - Privacy