Results 111 to 120 of about 670,128 (291)

Amino Acid and Fatty Acid Compositions of Sea Cucumber Stichopus Vastus from Salemo Island Waters, Indonesia

Squalen, 2018
Coastal waters of Indonesia have considerable biodiversity of sea cucumbers. In the present study the amino acid and fatty acid contents in sea cucumber Stichopus vastus collected from Salemo Island waters Indonesia were determined.
Abdullah Rasyid
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Order of amino acids in C-terminal cysteine-containing peptide-based chelators influences cellular processing and biodistribution of 99mTc-labeled recombinant Affibody molecules

, 2011
Affibody molecules constitute a novel class of molecular display selected affinity proteins based on non-immunoglobulin scaffold. Preclinical investigations and pilot clinical data have demonstrated that Affibody molecules provide high contrast imaging ...
Altai, Mohamed,, Wållberg, Helena, Rosestedt, Maria,, Helena Wållberg, Hosseinimehr, Seyed Jalal,, Vladimir Tolmachev, Tolmachev, Vladimir, Maria Rosestedt, Stefan Ståhl, Tolmachev, Vladimir,, Rosestedt, Maria, Ståhl, Stefan,, Mohamed Altai, Orlova, Anna, Wållberg, Helena,, Hosseinimehr, Seyed Jalal, Orlova, Anna,, Anna Orlova, Ståhl, Stefan, Altai, Mohamed, Seyed Jalal Hosseinimehr   +20 more
core   +1 more source

The role of abnormal amino acid metabolism in the occurrence and development of tumors

Frontiers in Oncology
The proliferation, migration, and invasion of tumor cells require a large amount of nutrients. Among them, the uptake of amino acids is crucial for most cellular functions, such as protein synthesis and cell growth.
Yuting Zhang, Honglin Chen
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Дослідження амінокислот стебел, листя та квіток лізіантусу Рассела

Annals of Mechnikov's Institute
Introduction. Amino acids have an immunomodulatory, antidepressant effect, they are components of collagen, reduce the level of triglycerides in the blood, take an active part in the synthesis and assimilation of vitamins, etc. Natural amino acids have a
Anna Olefirenko, Viktoria Kyslychenko
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The effect of oral essential amino acids on incretin hormone production in youth and ageing

, 2019
BackgroundThe effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.MethodsA 15‐g oral EAA drink was administered to young (N = 8; 26 ± 4.4 years) and older ...
Stokes, Tanner, Stefan H.M. Gorissen (12591649), Abdulla, H., Stuart M. Phillips, Stefan H. M. Gorissen, Stuart M. Phillips (261257), Bass, J.J., Chris McGlory (6939368), Gorissen, Stefan H M, Gorissen, S.H.M., Smith, Kenneth, Bethan E. Phillips, Abdulla, Haitham, Atherton, Philip J, Haitham Abdulla, Tanner Stokes, McGlory, C., Iskandar Idris, Joseph J. Bass (12591379), Phillips, Stuart M, Tanner Stokes (10488638), Kenneth Smith, Kenneth Smith (149075), Smith, K., McGlory, Chris, Stokes, T., Chris McGlory, Idris, Iskandar, Bethan E. Phillips (8620080), Idris, I., Phillips, B.E., Phillips, Bethan E, Phillips, S.M., Haitham Abdulla (12591646), Philip J. Atherton (7240463), Bass, Joseph J, Philip J. Atherton, Joseph J. Bass, Iskandar Idris (2564347), Atherton, P.J.   +39 more
core   +1 more source