Results 71 to 80 of about 58,526 (293)

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro   +7 more
wiley   +1 more source

Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides

open access: yesJournal of Lipid Research, 2003
Most preterm infant formulas contain medium-chain triacylglycerols (M80), but the effects of MCT on polyunsaturated fatty acid status and metabolism are controversial. Thus, we studied the effects of MCT on linoleic acid metabolism using stable isotopes.
Maria Rodriguez   +6 more
doaj   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

open access: yesAdvanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi   +12 more
wiley   +1 more source

The Possible Role of 3-lodothyronamine in Browning of Inguinal White Adipose Tissue in Mice

open access: yesEndocrinology Research and Practice, 2017
Purpose: In this study, we have investigated whether administration of a chronic low dose of 3-iodothyronamine (T1AM) could regulate the concentration of uncoupling protein 1 (UCP1) in mice inguinal white adipose tissue (IWAT).
Neda ESKANDARZADE   +3 more
doaj   +1 more source

Dynamic fecal microenvironment properties enable predictions and understanding of peripartum blood oxidative status and non-esterified fatty acids in dairy cows

open access: yes, 2023
Supplementary tables for Dynamic fecal microenvironment properties enable predictions and understanding of peripartum blood oxidative status and non-esterified fatty acids in dairy cows. 
Senlin Zhu (14158593)
core   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

open access: yesAdvanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang   +8 more
wiley   +1 more source

Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues

open access: yesGenetics Selection Evolution, 2011
Background Endocrine tissues play a fundamental role in maintaining homeostasis of plasma metabolites such as non-esterified fatty acids and glucose, the levels of which reflect the energy balance or the health status of animals.
Bassols Anna   +3 more
doaj   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

open access: yesAdvanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang   +9 more
wiley   +1 more source

BLOOD BIOMARKERS OF SHOW AND RACING EQUINE STALLIONS IN IRAQ: A COMPARATIVE STUDY

open access: yesThe Iraqi Journal of Agricultural science
A comparative study was conducted to detect blood metabolic biomarkers of show and racehorse stallions in Iraq. Five stallions were selected for each, and blood samples were collected via jugular venipuncture twice a time, fourteen days apart.
doaj   +1 more source

Insulin response and changes in composition of non-esterified fatty acids in blood plasma of middle-aged men following isoenergetic fatty and carbohydrate breakfasts

open access: yes, 2000
It was previously shown that a high plasma concentration of non-esterified fatty acids (NEFA) persisted after a fatty breakfast, but not after an isoenergetic carbohydrate breakfast, adversely affecting glucose tolerance.
Williams, NR   +5 more
core  

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