Results 51 to 60 of about 534,262 (294)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Discover Global SocietyWest Bengal in India is one of the worst impacted states by the cyclones. The first super cyclone after the 1999 super cyclone was in May 2020, called cyclone Amphan, which devastated West Bengal to its core, especially the North 24 Parganas and South 24
Tisha Goswami, Zafar Tabrez
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Fostering creativity in kindergarten: The impact of collaborative project-based learning
South African Journal of Childhood EducationBackground: Early childhood education (ECE) is crucial in cultivating creativity, especially in today’s tech-savvy world. This study explores the impact of collaborative project-based learning (PjBL) with computer and play motivation on kindergarten ...
Parwoto Parwoto +3 more
doaj +1 more source
Managing Formal, Non-Formal and Informal Economic Education [PDF]
Revista de Management Comparat International, 2013 If we consider how to effectively deal with economic education, we should start with the questions that entrepreneurs ask themselves when they start a business. Their goal is to make it profitable.
Monica Elisabeta PĂDURARU
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Discover PsychologyStudent well-being has become a central issue in higher education as universities confront rising concerns about academic stress, mental health, and student resilience.
Diana Rahmasari +4 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Paradoxes of Students’ Non-formal Education
Интеграция образования, 2019 Introduction. The research topicality lies in the inference that formal education system loses its ability to respond quickly to socio-cultural and technological changes in society.
Galina Z. Efimova +3 more
doaj +1 more source