Results 31 to 40 of about 594,076 (260)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Village fund management strategies for optimizing village original income to support community empowerment in Sambirejo Village, Indonesia

Journal of Community Service and Empowerment
This study examined how Village Funds (Dana Desa) were managed in Sambirejo Village, Prambanan, Sleman, to optimize Village Original Income (PADes) and strengthen community empowerment.
Abdah Rahmawati, Iis Prasetyo
doaj   +1 more source

IMPROVING EARLY CHILDHOOD COGNITIVE ABILITIES THROUGH HAND MOVEMENT METHOD

Empowerment, 2021
The purpose of this study was to examine how early childhood cognitive ability development occurs in case 1) Memory 2) Recognize numbers and their sequences, and 3) Application of educational materials in everyday life.
Ratna Lina Marliana, Nandang Rukanda, Sri Nurhayati   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Social inclusion of ethnic minorities through non – formal education [PDF]

Trakia Journal of Sciences, 2017
This article is provoked by the widening scope of non-formal education and its impact on the social inclusion of vulnerable groups, with a focus on ethnic minorities.
V. Mareva
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Participatory-based management of village-owned enterprises to optimize village original revenue: A case study of Tridadi Makmur, Sleman, Indonesia

Journal of Community Service and Empowerment
Village-owned enterprises have been positioned as strategic instruments for strengthening local economic autonomy, yet many village enterprises in Indonesia still struggle to contribute meaningfully to village original revenue.
M. Murtodo, Puji Yanti Fauziah
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Non-Formal Education as a Discipline

SPEKTRUM: Jurnal Pendidikan Luar Sekolah (PLS)
This article tries to explore the epistemology of science, ontology of science, and axiology of science. Looking at these three things, we try to present the epistemology of science, ontology of science, and axiology of science from the perspective of non-formal education. Pedagogical ontology examines the nature of education.
Putri Julita Mina Harafah, Setiawati Setiawati   +1 more
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source