Results 61 to 70 of about 2,541,010 (310)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Teaching Journalism in Ukraine: Between Formal and Non-Formal Education [PDF]

open access: yesGlobal Media Journal: German Edition, 2018
Formal journalism education in Ukraine has be en criticized for quite a long time for still being affected by the old Soviet theory-based teac hing model, rather than adhering to internation- ally accepted best practices. The system of teaching
Olena Demchenko
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Non-formal adult education: a new social and еducation phenomenon [PDF]

open access: yes, 2013
Автор розкриває поняття неформальної освіти, в основі якої є гуманістичний підхід і особистісно-орієнтована педагогіка. Неформальна освіта спрямована на адаптацію людини до швидкоплинного соціально-економічного середовища, її інтеграцію в соціум ...
Василенко, Олена Вікторівна
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Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Health education through non - formal education.

open access: yesAncient science of life, 2012
The non-availability of health care in the rural area leads to the problems like infant mortality, infectious disease deaths and malnutrition. Rural health can be promoted both at preventive and promotive levels through non-formal education.
P S, Sundararaj, P S, Kumar
openaire   +1 more source

Participation of Foreign Graduate Students in Campus-Based Non-Formal Education Programmes in Universiti Putra Malaysia [PDF]

open access: yes, 2008
This study examined participation in campus based non-formal education programmes among foreign graduate students in Universiti Putra Malaysia and its correlates.
Amadhila, Helena Naitsuwe
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Drug education : an entitlement for all : a report to government by the Advisory Group on Drug and Alcohol Education [PDF]

open access: yes, 2008
Drug And Alcohol Advisory Group – Key Recommendations: ●● Increase parents’ and carers’ knowledge and skills about drug and alcohol education and prevention enabling them to better inform and protect their children; ●● Improve the quality of drug and ...

core  

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