Results 61 to 70 of about 120,353 (299)

Supaglutide alleviates hepatic steatosis in monkeys with spontaneous MASH

Diabetology & Metabolic Syndrome
Background Glucagon-like peptide 1 (GLP-1) is an incretin hormone and plays an important role in regulating glucose homeostasis. GLP-1 has a short half-life due to degrading enzyme dipeptidyl peptidase-IV and rapid kidney clearance, which limits its ...
Qinghua Wang, Yue Zhou, Yunzhi Ni, Zhihong Wang, Yan-Ru Lou, Zunyuan Yang, Li Gong, Yinan Liang, Wen Zeng, Gerald J. Prud’homme   +9 more
doaj   +1 more source

A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques

Research
Nonsuicidal self-injury (NSSI) demonstrates escalating prevalence among adolescents as a maladaptive behavior characterized by deliberate self-harm, yet its neurobiological underpinnings remain elusive.
Ya-Li Zhang, Yi-Cheng Qiao, Yun-Chao Ji, Hong-Di Huang, Long Zhang, Jian-Xiong Ruan, Chen-Yao Li, Hui-Heng Xie, Bao-Lin Zhang, Qi Zhou, Sha-Sha Yue, Xiao-Mei Yu, Ming-Hao Qiu, Chuan-Kai Yu, Si-Chu Wu, Yu-Fang Zhou, Yan-Ling Li, Hong-Mei Zhu, Shu-Zhen Dong, Kang Huang, Yun Wang, Qiong Wang, Yi-Jiang Li, Ya Xie, Hui-Ling Chen, Long-Bao Lv, Shu Liu, Yong-Gang Yao, Chun Wang, Ning Liu, Jian-Hong Wang   +30 more
doaj   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1 G93A mice

Journal of Nanobiotechnology
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking.
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou   +10 more
doaj   +1 more source

Abnormal outer and inner retina in a mouse model of Huntington’s disease with age

Frontiers in Aging Neuroscience
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction and cognitive decline. While retinal abnormalities have been documented in some HD patients and animal models, the nature of these abnormalities ...
Dashuang Yang, Chunhui Huang, Chunhui Huang, Xuemeng Guo, Yintian Li, Jiaxi Wu, Zaijun Zhang, Zaijun Zhang, Zaijun Zhang, Sen Yan, Ying Xu, Ying Xu   +11 more
doaj   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Improved Simultaneous Multislice EPI Reconstruction for Diffusion MRI using regularized iterative phase error-corrected SENSE

NeuroImage
Simultaneous multi-slice echo planar imaging (SMS-EPI) has significantly advanced diffusion MRI by enabling efficient whole-brain coverage at high spatial resolution.
Mengqi Wang, Yunlin Zhao, Mengye Lyu, Ed X. Wu, Yilong Liu   +4 more
doaj   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease

Translational Neurodegeneration
Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors.
Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin   +5 more
doaj   +1 more source