Results 111 to 120 of about 156,532 (260)

Reemergence of yellow fever in the state of São Paulo: the structuring role of surveillance of epizootics in non-human primates in a one health approach [PDF]

Revista Brasileira de Epidemiologia
Objective: to present a comprehensive analysis of YF occurrence of in the state of São Paulo since its reemergence, and the ongoing process of structuring the surveillance of epizootics in non-human primates in a one health approach.
Leila del Castillo Saad, Francisco Chiaravalloti-Neto   +1 more
doaj   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Depletion of giant ANK2 in monkeys causes drastic brain volume loss

Cell Discovery, 2021
Dong-Dong Qin, Jian-Kui Zhou, Xie-Chao He, Xiang-Yu Shen, Cong Li, Huan-Zhi Chen, Lan-Zhen Yan, Zheng-Fei Hu, Xiang Li, Long-Bao Lv, Yong-Gang Yao, Zheng Wang, Xing-Xu Huang, Xin-Tian Hu, Ping Zheng   +14 more
doaj   +1 more source

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source

Neuropsychology of perception and facial expression of emotions: studies with children and non human primates [PDF]

, 2004
Este estudio revisa diferentes investigaciones sobre la neuropsicología de la percepción y la expresión facial de emociones en niños y en primates no humanos.
Carvajal Molina, Fernando, Fernández Carriba, Samuel, Loeches Alonso, Ángela, Serrano Rodríguez, Juan Manuel   +3 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

Cell Discovery, 2022
Guanqin Ma, Deng-Feng Zhang, Qing-Cui Zou, Xiaochun Xie, Ling Xu, Xiao-Li Feng, Xiaohong Li, Jian-Bao Han, Dandan Yu, Zhong-Hua Deng, Wang Qu, Junyi Long, Ming-Hua Li, Yong-Gang Yao, Jianxiong Zeng   +14 more
doaj   +1 more source

Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates.

PLoS Neglected Tropical Diseases, 2018
Many human parasites and pathogens have closely related counterparts among non-human primates. For example, non-human primates harbour several species of malaria causing parasites of the genus Plasmodium.
Jyotsana Dixit, Arun Zachariah, Sajesh P K, Bathrachalam Chandramohan, Vinoth Shanmuganatham, K Praveen Karanth   +5 more
doaj   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Defining a core breath profile for healthy, non-human primates

Scientific Reports
Non-human primates remain the most useful and reliable pre-clinical model for many human diseases. Primate breath profiles have previously distinguished healthy animals from diseased, including non-human primates.
Carly A. Bobak, Keisean A. J. M. Stevenson, Ning Sun, Mohammad S. Khan, Jannatul Azmir, Marco Beccaria, Jaime A. Tomko, Daniel Fillmore, Charles A. Scanga, Philana L. Lin, JoAnne L. Flynn, Jane E. Hill   +11 more
doaj   +1 more source