Computer-driven development of an in silico tool for finding selective histone deacetylase 1 inhibitors [PDF]
, 2020 Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents.
Brogi, Simone +4 more
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Genetic and Functional Analysis of the Biosynthesis of a Non-Ribosomal Peptide Siderophore in Burkholderia xenovorans LB400. [PDF]
PLoS ONE, 2016 B. xenovorans LB400 is a model bacterium for the study of the metabolism of aromatic compounds. The aim of this study was the genomic and functional characterization of a non-ribosomal peptide synthetase containing gene cluster that encodes a siderophore
María José Vargas-Straube +5 more
doaj +1 more source
Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis. [PDF]
PLoS Pathogens, 2015 The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M.
Cressida A Madigan +9 more
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Biosynthesis Pathways, Transport Mechanisms and Biotechnological Applications of Fungal Siderophores
Journal of Fungi, 2021 Iron (Fe) is the fourth most abundant element on earth and represents an essential nutrient for life. As a fundamental mineral element for cell growth and development, iron is available for uptake as ferric ions, which are usually oxidized into complex ...
Lorenzo Pecoraro +8 more
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Switching the Switch: Ligand Induced Disulfide Formation in HDAC8 [PDF]
, 2020 Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is ...
Ballweg, Matthias +8 more
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A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis. [PDF]
PLoS ONE, 2017 Development of adipose tissue requires the differentiation of less specialized cells, such as human mesenchymal stem cells (hMSCs), into adipocytes.
Dale B Bosco +6 more
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Identification of novel molecular scaffolds for the design of MMP-13 inhibitors through Virtual Screening Methods [PDF]
, 2010 Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients. It is characterized by progressive loss of articular cartilage that eventually leads to denudation of the joint surface.
La Pietra, Valeria
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A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877. [PDF]
PLoS ONE, 2014 The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier protein domains of the polyketide synthases (PKS), non ribosomal peptide synthases (NRPS) and fatty acid synthases (FAS).
Robert Bunet +9 more
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Challenges in matrix metalloproteinases inhibition [PDF]
, 2020 SAICT-POL/24288/2016 UIDB/50006/2020 UID/Multi/04378/2019Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization.
Azul, Ana Cristina +7 more
core +2 more sources
The stringent response and cell cycle arrest in Escherichia coli. [PDF]
PLoS Genetics, 2008 The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp. We characterize the replication arrest that occurs during the stringent response in Escherichia coli.
Daniel J Ferullo, Susan T Lovett
doaj +1 more source