Results 61 to 70 of about 8,600 (184)
Chemical Ligation of Backbone N‐hydroxylated Peptides
Chemistry – A European Journal, EarlyView.Peptide backbone N‐hydroxylation enables sequence‐agnostic fragment ligation via hydroxamate O‐acyl capture and O→N acyl transfer in water. Broad tolerance of sterically demanding nucleophilic residues is observed, and reductive N─O cleavage restores the native amide bond.
Natalia Cano‐Sampaio +1 more
wiley +1 more source
Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
PLoS ONE, 2012 BackgroundTargeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed.
Lynda Mezil +9 more
doaj +1 more source
New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold
Bioorganic & Medicinal Chemistry Letters, 2010 In this Letter we describe the design, synthesis, screening, and optimization of a new family of ADAMTS-5 inhibitors. These inhibitors display an original 1,2,4-triazole-3-thiol scaffold as a putative zinc binding-group. In vitro results are rationalized by in silico docking of the compounds in ADAMTS-5's crystal structure.
Maingot, L +8 more
openaire +2 more sources
Matrix metalloproteinase inhibitors: current developments and future perspectives [PDF]
, 2001 Malignant tumors are characterized by invasive growth and metastasis. To facilitate this invasive behavior, the enzymatic breakdown of the extracellular matrix (ECM) is a prerequisite.
Eskens, F.A.L.M. (Ferry) +2 more
core +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.This review elucidates the molecular mechanisms of algicidal bacteria, highlighting critical behaviours like chemotaxis, quorum sensing and extracellular vesicle release. It details how these actions disrupt algal cellular integrity, photosynthesis and calcium homeostasis, providing a theoretical foundation for controlling harmful algal blooms ...
Jiaxin Wang, Binfu Xu, Lixing Huang
wiley +1 more source
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit [PDF]
, 2020 A series of potent inhibitors of histone deacetylase-8 (HDAC8) is described that contains an α-amino amide zinc-binding unit and a substituted isoindolinyl capping group. The presence of a 2,4-dichlorophenyl unit located in the acetate-release cavity was
Chan, AWE +3 more
core
Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulence [PDF]
, 2004 Systemic anthrax infections can be characterized as proceeding in stages, beginning with an early intracellular establishment stage within phagocytes that is followed by extracelluar stages involving massive bacteraemia, sepsis and death.
Cendrowski, Stephen +2 more
core +1 more source
Entwicklung neuer Strategien zur spezifischen Hemmung humaner Histondeacetylase 8 [PDF]
, 2023 Die Deacetylierung von Histonen ist ein wichtiger Mechanismus für die Regulation von Genen und der daraus resultierenden Transkription und Translation in funktionelle Proteine. Die Deacetylierung von Histonen wird durch die sogenannten Histondeacetylasen
Jänsch, Niklas
core +1 more source
Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.Compost derived Bacillus isolates were screened for plant growth promoting traits, scored through modelling and validated in field trials on maize and okra. Selected strains enhanced growth significantly, enabling reduced chemical fertiliser use, ecofriendly bioinputs and improved soil health.
Debapriya Maitra +9 more
wiley +1 more source