Results 81 to 90 of about 8,600 (184)
Journal of Enzyme Inhibition and Medicinal ChemistryA series of triazole-tethered triazines bearing pharmacophoric features of DNA-targeting agents and non-hydroxamate MMPs inhibitors were synthesized and screened against HCT-116, Caco-2 cells, and normal colonocytes by MTT assay.
Christine A. Morcos +7 more
doaj +1 more source
Haematologica, 2017 Histone deacetylase inhibitors are members of a class of epigenetic drugs that have proven activity in T-cell malignancies, but little is known about their efficacy in B-cell lymphomas.
Vincent Ribrag +14 more
doaj +1 more source
Methods for Detection of Matrix Metalloproteinases as Biomarkers in Cardiovascular Disease [PDF]
, 2008 Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that degrade extracellular matrix (ECM) components like collagen, fibronectin, and laminin.
Lopez-Avila, Viorica, Spencer, Juliet
core +2 more sources
Synthesis of New Planar-Chiral Linked [2.2]Paracyclophanes-N-([2.2]-Paracyclophanylcarbamoyl)-4-([2.2]Paracyclophanylcarboxamide, [2.2]Paracyclophanyl-Substituted Triazolthiones and -Substituted Oxadiazoles [PDF]
, 2020 The manuscript describes the synthesis of new racemic and chiral linked paracyclophane assigned as N-5-(1,4(1,4)-dibenzenacyclohexaphane-12-yl)carbamoyl)-5’-(1,4(1,4)-dibenzenacyclohexaphane-12-yl)carboxamide. The procedure depends upon the reaction of 5-
Aly, Ashraf A. +5 more
core +4 more sources
A Scalable and Sustainable Synthesis of Indirubin Frameworks Enabled by Deep Eutectic Solvents
ChemSusChem, Volume 19, Issue 1, January 2026.A sustainable protocol for the synthesis of indirubin in a choline chloride/urea deep eutectic solvent at 70°C under air affords the product in 70% yield without chromatography. The method is robust, scalable to pilot scale, and enables late‐stage functionalization, granting access to a wide range of indirubin derivatives. CHEM21 green metrics validate
Biagio Delvecchio +5 more
wiley +1 more source
Frontiers in Microbiology, 2018 The ubiquitous mold Scedosporium apiospermum is increasingly recognized as an emerging pathogen, especially among patients with underlying disorders such as immunodeficiency or cystic fibrosis (CF). Indeed, it ranks the second among the filamentous fungi
Yohann Le Govic +10 more
doaj +1 more source
Journal of Molecular Recognition, Volume 39, Issue 1, January 2026.ABSTRACT Sirtuin 6 (SIRT6) is an enzyme belonging to the class of nicotinamide adenine dinucleotide (NAD+) dependent histone deacetylases. It has been of interest due to its multivariate biological role and association with aging‐related diseases and metabolic dysfunctions.
Érika Geicianny de Carvalho Matias +5 more
wiley +1 more source
Polymeric Nanoparticles for the Diagnosis and Treatment of Snakebite
Macromolecular Chemistry and Physics, Volume 227, Issue 1, 15 January 2026.Snakebite envenomation affects between 1.8 and 5.5 million people annually, many of whom suffer disabilities or even death. Current antivenoms are composed of plasma‐derived antibodies. However, there remains an underexplored opportunity to utilise polymer‐based nanoparticles.
Neil Prabhakar +2 more
wiley +1 more source
Evaluation of 89Zr-Labeled Anti-PD-L1 Monoclonal Antibodies Using DFO and Novel HOPO Analogues as Chelating Agents for Immuno-PET [PDF]
, 2023 Programmed death ligand 1 (PD-L1) is a type 1 transmembrane immunosuppressive protein that is expressed on a wide range of cell types, including cancer cells.
Alauddin, Mian +7 more
core +1 more source
Expression, enzymatic activity, and inhibition of MMP-3 in C6-13 rat glioma cells [PDF]
, 2018 Glioblastoma multiforme is the most aggressive form of brain cancer due to high rates of reoccurrence. Although >95% of a tumor can be removed with surgery, the invasiveness of gliomas frequently leads to the formation of tumors at secondary sites.
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