Results 11 to 20 of about 56,421 (265)

Interplay Between Sub-Cellular Alterations of Calcium Release and T-Tubular Defects in Cardiac Diseases

open access: yesFrontiers in Physiology, 2018
Asynchronous Ca2+ release promotes non-homogeneous myofilament activation, leading to mechanical dysfunction, as well as initiation of propagated calcium waves and arrhythmias.
Marina Scardigli   +9 more
doaj   +1 more source

Tailored Sample Mounting for Light-Sheet Fluorescence Microscopy of Clarified Specimens by Polydimethylsiloxane Casting

open access: yesFrontiers in Neuroanatomy, 2019
The combination of biological tissue clearing methods with light-sheet fluorescence microscopy (LSFM) allows acquiring images of specific biological structures of interest at whole organ scale and microscopic resolution.
Antonino Paolo Di Giovanna   +9 more
doaj   +1 more source

Quantitative neuroanatomy of all Purkinje cells with light sheet microscopy and high-throughput image analysis

open access: yesFrontiers in Neuroanatomy, 2015
Characterizing the cytoarchitecture of mammalian central nervous system on a brain-wide scale is becoming a compelling need in neuroscience. For example, realistic modeling of brain activity requires the definition of quantitative features of large ...
Ludovico eSilvestri   +10 more
doaj   +1 more source

Data on the target search by a single protein on DNA measured with ultrafast force-clamp spectroscopy

open access: yesData in Brief, 2019
The mechanism by which proteins are able to find small cognate sequences in the range from few to few tens of base pairs amongst the millions of non-specific chromosomal DNA has been puzzling researchers for decades.
Carina Monico   +4 more
doaj   +1 more source

Quantifying the Sensitivity and Unclonability of Optical Physical Unclonable Functions

open access: yesAdvanced Photonics Research, 2023
Due to their unmatched entropy, complexity, and security level, optical physical unclonable functions (PUFs) currently receive a lot of interest in the literature.
Giuseppe Emanuele Lio   +6 more
doaj   +1 more source

Brain-wide neuron quantification toolkit reveals strong sexual dimorphism in the evolution of fear memory

open access: yesCell Reports, 2023
Summary: Fear responses are functionally adaptive behaviors that are strengthened as memories. Indeed, detailed knowledge of the neural circuitry modulating fear memory could be the turning point for the comprehension of this emotion and its pathological
Alessandra Franceschini   +9 more
doaj   +1 more source

Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts

open access: yesFrontiers in Neuroanatomy, 2019
The development of light-sheet fluorescence microscopy (LSFM) has greatly expanded the experimental capabilities in many biological and biomedical research fields, enabling for example live studies of murine and zebrafish neural activity or of cell ...
Giuseppe Sancataldo   +18 more
doaj   +1 more source

Myosin V fluorescence imaging dataset for single-molecule localization and tracking

open access: yesData in Brief, 2019
Myosin-5B is one of three members of the myosin-5 family of actin-based molecular motors fundamental in recycling endosome trafficking and collective actin network dynamics. Through single-molecule motility assays, we recently demonstrated that myosin-5B
Lucia Gardini   +3 more
doaj   +1 more source

Optogenetic manipulation of cardiac repolarization gradients using sub-threshold illumination

open access: yesFrontiers in Physiology, 2023
Introduction: Mechanisms underlying cardiac arrhythmias are typically driven by abnormalities in cardiac conduction and/or heterogeneities in repolarization time (RT) across the heart. While conduction slowing can be caused by either electrophysiological
Gerard A. Marchal   +9 more
doaj   +1 more source

Ultrafast all-optical generation of pure spin and valley currents

open access: yesnpj 2D Materials and Applications
Pure currents comprise the flow of a two state quantum freedom – for example the electron spin – in the absence of charge flow. Radically different from the charge currents that underpin present day electronics, in two dimensional materials possessing ...
D. Gill   +3 more
doaj   +1 more source

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