Results 71 to 80 of about 12,574,839 (304)

Free-form optics for non-idealized light sources in 3D: A phase-space approach

open access: yes, 2022
Paper 106930J, 7 S.Free-form optics have been proven to be a very powerful and efficient illumination strategy with applications ranging from automotive and architecture illumination to laser beam shaping. State of the art free-form optics design methods
Völl, A.   +5 more
core   +1 more source

Mapping brain state-dependent sensory responses across the mouse cortex

open access: yesiScience
Summary: Sensory information must be integrated across a distributed brain network for stimulus processing and perception. Recent studies have revealed specific spatiotemporal patterns of cortical activation for the early and late components of sensory ...
Elena Montagni   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

POLARIZED NON-LINEAR OPTICS OF NON-LOCAL MEDIA

open access: yes, 1992
The aim of the work is to investigate theoretically the effects of the light interconnection with substance stipulated by a space dispersion of the optic non-linearity.
Svirko, Yury Petrovich
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Theory of Non-linear Optical Response in Molecular Layers

open access: yes, 1991
Nonlinear optics has provided a useful testing ground for the concept of molecular engineering. One seeks to design and synthesize molecules of high nonlinear optical response, and then to fabricate a molecular material in which this response is ...
Munn, RW   +2 more
core  

Non-Abelian gauge field optics

open access: yes, 2018
The concept of gauge field is a cornerstone of modern physics and the synthetic gauge field has emerged as a new way to manipulate particles in many disciplines. In optics, several schemes of Abelian synthetic gauge fields have been proposed.
Jian Qi Shen (17489643)   +6 more
core   +1 more source

Peak response of non-linear oscillators under stationary white noise [PDF]

open access: yes, 2007
YesThe use of the Advanced Censored Closure (ACC) technique, recently proposed by the authors for predicting the peak response of linear structures vibrating under random processes, is extended to the case of non-linear oscillators driven by stationary ...
Palmeri, Alessandro, Muscolino, G.
core   +1 more source

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