Results 41 to 50 of about 320,284 (261)

Validation of a self‐completed Dystonia Non‐Motor Symptoms Questionnaire

Annals of Clinical and Translational Neurology, 2019
Objective To develop and validate a novel 14‐item self‐completed questionnaire (in English and German) enquiring about the presence of non‐motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter
Lisa Klingelhoefer, Kallol R. Chaudhuri, Christoph Kamm, Pablo Martinez‐Martin, Kailash Bhatia, Anna Sauerbier, Maximilian Kaiser, Carmen Rodriguez‐Blazquez, Bettina Balint, Robert Untucht, Lynsey J. Hall, Lauritz Mildenstein, Miriam Wienecke, Davide Martino, Olaf Gregor, Alexander Storch, Heinz Reichmann   +16 more
doaj   +1 more source

Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2018
Though Parkinson’s disease (PD) clinical picture is generally dominated by motor impairment, non-motor symptoms, such as cognitive decline and gastrointestinal dysfunctions, may develop before motor symptoms and have major effects on quality of life. L-3,
Paula Perez-Pardo, Laus M. Broersen, Laus M. Broersen, Tessa Kliest, Nick van Wijk, Amos Attali, Johan Garssen, Johan Garssen, Aletta D. Kraneveld   +8 more
doaj   +1 more source

Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History

Medicina
Background/Objectives: A family history of Parkinson’s disease (PD) is an important risk factor for developing PD. Because only a few studies have investigated the clinical characteristics of PD patients based on family history, this study compared the ...
Hyunsoo Kim, Seong-Min Choi, Hak-Loh Lee, Soo Hyun Cho, Byeong C. Kim   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Spotlight on non-motor symptoms and Covid-19

, 2022
The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although ...
Rota, Silvia, Boura, Iro, Wan, Yi Min, Lazcano-Ocampo, Claudia, Rodriguez-Violante, Mayela, Antonini, Angelo, Chaudhuri, Kallol Ray   +6 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Multidimensional Factors Can Explain the Clinical Worsening in People With Parkinson's Disease During the COVID-19 Pandemic: A Multicenter Cross-Sectional Trial

Frontiers in Neurology, 2021
Background: Self-reported clinical worsening by people with Parkinson's disease (PD) during social distancing may be aggravated in Brazil, where the e/tele-health system is precarious.Objectives: This study aims to investigate self-reported changes in ...
Carla Silva-Batista, Daniel Boari Coelho, Renato Campos Freire Júnior, Lorena Rosa Almeida, Lorena Rosa Almeida, Adriana Guimarães, Katia Cirilo Costa Nóbrega, Hugo Machado Sanchez, Ana Raquel Rodrigues Lindquist, Vera Lúcia Israel, Hélcio Kanegusuku, Rachel Guimarães, Nayanne Beckmann Bosaipo, Richelma Barbosa, Clynton Lourenço Correa, Maria José Finatto, Felipe Augusto dos Santos Mendes, Maria Elisa Pimentel Piemonte   +17 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Factors Contributing to Malnutrition in Parkinson's Disease Patients With Freezing of Gait

Frontiers in Neurology, 2022
Background and PurposeLittle is known about the nutritional status and clinical characteristics of patients with Parkinson's disease with freezing of gait (PDFOG).
Li-Li Zhang, Li-Li Zhang, Li-Li Zhang, Liang Zhang, Jingde Dong, Ying Zhao, Xiao-Ping Wang   +6 more
doaj   +1 more source

Non-motor symptoms in dystonia

, 2022
Dystonia is a movement disorder in which patients suffer from involuntary repetitive movements and/or abnormal postures. In addition to the problems with movement, patients also have non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue. These non-motor symptoms often remain underexposed, but they do have a great influence on the
openaire   +1 more source