Phenotypic Variability in Autosomal Dominant Familial Alzheimer Disease due to the S170F Mutation of Presenilin-1 [PDF]
, 2018 Background: In rare cases, patients with Alzheimer disease (AD) present at an early age and with a family history suggestive of an autosomal dominant mode of inheritance.
Benjamin, Beate +3 more
core +1 more source
Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
Frontiers in Aging Neuroscience, 2018 Though Parkinson’s disease (PD) clinical picture is generally dominated by motor impairment, non-motor symptoms, such as cognitive decline and gastrointestinal dysfunctions, may develop before motor symptoms and have major effects on quality of life. L-3,
Paula Perez-Pardo +8 more
doaj +1 more source
Relation of Parkinson\u27s Disease Subtypes to Visual Activities of Daily Living [PDF]
, 2011 Visual perceptual problems are common in Parkinson\u27s disease (PD) and often affect activities of daily living (ADLs). PD patients with non-tremor symptoms at disease onset (i.e., rigidity, bradykinesia, gait disturbance or postural instability) have ...
Cronin-Golomb, Alice +5 more
core +2 more sources
Non-motor symptoms in parkinson’s disease [PDF]
Саратовский научно-медицинский журнал, 2012 <p>The goal of the research was to investigate some non-motor disorders at patients with Parkinson disease (PD) and to determine their relations to the main manifestations of the disease. 68 patients with PD without dementia were studied.
Baidina T.V., Torgan T.I.
doaj
Validation of a self‐completed Dystonia Non‐Motor Symptoms Questionnaire
Annals of Clinical and Translational Neurology, 2019 Objective To develop and validate a novel 14‐item self‐completed questionnaire (in English and German) enquiring about the presence of non‐motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter
Lisa Klingelhoefer +16 more
doaj +1 more source
Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms
Frontiers in Aging Neuroscience, 2017 Parkinson's disease is now considered a complex, multi-peptide, central, and peripheral nervous system disorder with considerable clinical heterogeneity. Non-motor symptoms play a key role in the trajectory of Parkinson's disease, from prodromal premotor
Jesse Mu +5 more
doaj +1 more source
The therapeutic potential of exercise to improve mood, cognition, and sleep in Parkinson's disease [PDF]
, 2015 Published in final edited form as: Mov Disord. 2016 January ; 31(1): 23–38. doi:10.1002/mds.26484.In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of ...
Cronin‐Golomb, Alice +3 more
core +1 more source
Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History
MedicinaBackground/Objectives: A family history of Parkinson’s disease (PD) is an important risk factor for developing PD. Because only a few studies have investigated the clinical characteristics of PD patients based on family history, this study compared the ...
Hyunsoo Kim +4 more
doaj +1 more source
Neurocognitive Predictors of Treatment Response to Randomized Treatment in Adults with Tic Disorders [PDF]
, 2017 Tourette\u27s disorder (TS) and chronic tic disorder (CTD) are neurodevelopmental disorders characterized by involuntary vocal and motor tics. Consequently, TS/CTD have been conceptualized as disorders of cognitive and motor inhibitory control.
Abramovitch, Amitai +9 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu +8 more
wiley +1 more source