Results 81 to 90 of about 12,797,283 (292)

Fatigue in patients with Parkinson’s disease: a cross-sectional study

Frontiers in Aging Neuroscience
ObjectiveThe purpose of this study is to ascertain the incidence of fatigue and to determine the cross-sectional associate and related variables of fatigue in patients with Parkinson’s disease (PD).MethodsA sample of 130 healthy individuals (39.23% male,
Haibo Ning, Lei Chen, Lei Chen, Min Wang, Min Wang, Ning Lv, Lihua Chen   +6 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Assessment of Early Stage Non-Motor Symptoms in Parkinson's Disease [PDF]

, 2013
Objective: In this study, our purpose is to asses the frequency of non-motor symptoms and to discuss its effect on the morbidity of the disease. Material and Met-hod: We included 80 Parkinson's patients diagnosed according to the United Kingdom Brain ...
Akpinar, Zehra, Gumus, Haluk, Demir, Orhan   +2 more
core   +1 more source

Advances in autonomic dysfunction research in Parkinson’s disease

Frontiers in Aging Neuroscience
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, best known for its motor symptoms such as resting tremor, muscle rigidity, and bradykinesia.
Hongjia Xu, Xiaolei Zheng, Xinyue Xing, Zhichao Bi, Dewei Wang, Cheng Zhang, Lifei Wei, Yulin Jin, Shunliang Xu, Shunliang Xu   +9 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Sex Differences in Parkinson’s Disease: A Narrative Review

Neurology and Therapy
Sex differences in epidemiology, clinical features, and therapeutical responses are emerging in several movement disorders, even though they are still not widely recognized.
Carlo Cattaneo, Javier Pagonabarraga
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson's disease

The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson's disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study,
Loehrer, Philipp A, Rizos, Alexandra, Martinez-Martin, Pablo, Nimsky, Christopher, Fink, Gereon R, International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group, Herberg, Johanna, Silverdale, Monty, Tinazzi Michele, Visser-Vandewalle, Veerle, Stopic, Vasilija, Jost, Stefanie T, Ray Chaudhuri, K, Petry-Schmelzer, Jan Niklas, Schrag, Anette, Gronostay, Alexandra, Timmermann, Lars, Dafsari, Haidar S, Sauerbier, Anna, Antonini, Angelo, as group member, EUROPAR, the German Parkinson Society Non-motor Symptoms Study Group, Evans, Julian, Weintraub, Daniel, Schneider, Christian, Ashkan, Keyoumars   +25 more
core   +1 more source

The non-motor symptoms questionnaire and non-motor symptoms scale for use in Sweden

, 2017
Objective: To translate the Non-Motor Symptoms Questionnaire (NMSQ) and the Non-Motor Symptoms Scale (NMSS) into Swedish, and test their linguistic validity and user-friendliness. Background: Non-motor symptoms (NMS) are common but under recognized among people with Parkinson’sdisease (PwPD).
Hagell, Peter, Nilsson, Maria, Chaudhuri, Ray, Odin, Per   +3 more
openaire   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source