Results 71 to 80 of about 654,324 (304)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Neuropsychiatric Disease and Treatment, 2021
Yu Cao,1,* Gongfeng Li,1,* Jinsheng Xue,2,* Guijuan Zhang,1 Sensen Gao,1 Yuling Huang,1 Aiqin Zhu1 1Institute of Geriatric, Qinghai Provincial People’s Hospital, Xining, People’s Republic of China; 2Foreign Cooperation Office, Chengdu Fifth ...
Cao Y, Li G, Xue J, Zhang G, Gao S, Huang Y, Zhu A   +6 more
doaj  

HOW THE FREQUENCY OF PAIN IN THE EARLY STAGES OF PARKINSON’S DISEASE AFFECTS THE SPEED OF DIAGNOSIS

İstanbul Tıp Fakültesi Dergisi, 2022
Objective: The fact that non-motor symptoms such as pain in Parkinson’s disease (PD) are more associated with musculoskeletal diseases (MSD) suggests that there may be delays in diagnosis.
Bedia Samancı, Nazlı Durmaz Çelik, Başar Bilgiç, Serhat Özkan, Haşmet Ayhan Hanağası   +4 more
doaj   +1 more source

The impact of sleep quality on cognitive functioning in Parkinson's disease [PDF]

, 2011
In healthy individuals and those with insomnia, poor sleep quality is associated with decrements in performance on tests of cognition, especially executive function. Sleep disturbances and cognitive deficits are both prevalent in Parkinson's disease (PD).
Bogdanova, Y., Cronin-Golomb, Alice, McNamara, P., Neargarder, S., Stavitsky, K.   +4 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

Frontiers in Aging Neuroscience
BackgroundParkinson’s disease (PD) is often associated with orthostatic hypotension (OH). However, research examining the relationship between OH and PD has yielded inconsistent results.
Hui Wang, Chi Zhang, Dongxun Xu
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease

BMC Neuroscience, 2019
Background Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life.
Flavia Niccolini, Heather Wilson, Beniamino Giordano, Konstantinos Diamantopoulos, Gennaro Pagano, Kallol Ray Chaudhuri, Marios Politis   +6 more
doaj   +1 more source

Effects of dual-task interventions on gait performance of patients with parkinson’s disease: a systematic review [PDF]

, 2016
OBJECTIVE: Parkinson’s disease is characterized by motor and non-motor symptoms that impair patients’ gait performance, especially while performing dual/concurrent tasks.
Bento, Teresa, Campos, Carlos, Lattari, Eduardo, Machado, Sérgio, Nardi, Antônio Egidio, Rocha, Nuno Barbosa F., Santos, Luís A. A.   +6 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source