Results 41 to 50 of about 146,209 (251)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Impact of Reciprocity in Information Spreading Using Epidemic Model Variants
Information, 2018 The use of online social networks has become a standard medium of social interactions and information spreading. Due to the significant amount of data available online, social network analysis has become apropos to the researchers of diverse domains to ...
Rishabh Narang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Ising model with non-reciprocal interactions
Effective interactions that violate Newton's third law of action-reaction symmetry are common in systems where interactions are mediated by a non-equilibrium environment. Extensive Monte Carlo simulations are carried out on a two-dimensional Ising model, where the interactions are modified non-reciprocally.
Rajeev, Agney K., Kumar, A. V. Anil
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Flocking with random non-reciprocal interactions
9 pages, 7 ...
Choi, Jiwon +2 more
openaire +2 more sources
Persistent Flows and Non-Reciprocal Interactions in Deterministic Networks
, 2017 This paper studies deterministic consensus networks with discrete-time dynamics under persistent flows and non-reciprocal agent interactions. An arc describing the interaction strength between two agents is said to be persistent if its weight function has an infinite $l_1$ norm. We discuss two balance conditions on the interactions between agents which
Xia, Weiguo +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Authority and Deliberative Moments: Assessing Equality and Inequality in Deeply Divided Groups
Journal of Deliberative Democracy, 2017 The notion of equality is central to public deliberation, but few researches have examined how participants construct interactions in face-to-face group discussion involving unequal conditions of authority.
Danila Cal +5 more
doaj +2 more sources