Results 131 to 140 of about 7,040,880 (266)
Non-eliminative Reductionism: Reconciling Qualia and Physicalism.
A physicalist view of qualia labelled non-eliminative reductionism is outlined. If it is true, qualia and physicalism can co-exist without difficulty. First, qualia present no particular problem for reductionist physicalism - they are entirely physical ...
Nicholson, Dennis
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Kripkenstein and Non-Reductionism about Meaning-Facts
, 2009 In 1982 Saul A. Kripke proposed a reconstruction of the central insights of Ludwig Wittgenstein's remarks on rule-following. The reconstruction prominently featured a sceptical challenge which soon was recognised as a new and very radical form of ...
Demont, Florian
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Reductionism in academic disciplines
, 1985 SIGLEAvailable from British Library Lending Division - LD:85/30454(Reductionism) / BLDSC - British Library Document Supply CentreGBUnited ...
Society for Research into Higher Education (SRHE), Guildford (United Kingdom) +1 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The Research on Naturalistic Non-Reductionism in Metaethics
, 2010 伦理自然主义非还原论是一种承认道德性质、道德事实真实存在的道德实在论。它反对将道德性质、道德事实还原为自然性质、自然事实,也反对将道德语言重新定义为自然语言。它不是摩尔在《伦理学原理》中批评的那种自然主义,是异于直觉主义和自然主义还原论的特殊理论。The non-reductionism in ethical naturalism is a kind of moral realism which acknowledges the real existence of moral properties ...
杨松
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