Results 111 to 120 of about 7,040,883 (266)
Czy podmiotowość epistemiczna ma znaczenie moralne? (DOES EPISTEMIC SUBJECTIVITY HAVE MORAL IMPORT?) [PDF]
Analiza i Egzystencja, 2007 We start from the basics: there is a meaning of the notion of epistemic subject under which it is not an object at all. This statement does not lead to dualism of substance; it fits with any sort of non-reductionism.
Piotr Bołtuć
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
O testemunho como fonte de justificação: um estudo sobre a epistemologia do testemunho [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Hmanas, Programa de Pós-Graduação em Filosofia, Florianópolis, 2013.O principal problema da epistemologia do testemunho é investigar a justificação que o ...
Moreira, Delvair Custódio
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The spiritual core of the hard problem: consciousness as foundational, not emergent
Frontiers in PsychologyThis paper proposes a transpersonal reframing of the Hard Problem of Consciousness by positing that consciousness is ontologically primary—not an emergent property of neural processes, but the foundational reality from which mind and matter arise ...
Amira Arora
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Reductionism in academic disciplines [PDF]
, 1985 SIGLEAvailable from British Library Lending Division - LD:85/30454(Reductionism) / BLDSC - British Library Document Supply CentreGBUnited ...
Society for Research into Higher Education (SRHE), Guildford (United Kingdom) +1 more
core
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source