Results 111 to 120 of about 10,367,564 (257)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Three concepts of power: Foucault, Bourdieu, and Habermas
Power and EducationThe article is a discussion of the concept of power in three different social theories that are often applied to educational research: the theories of Jürgen Habermas, Pierre Bourdieu, and Michel Foucault.
Gerd Christensen
doaj +1 more source
Jurnal Ceteris ParibusThis article presents a meta-critical synthesis of the paradigm shifts in life writing—encompassing both biography and autobiography—as documented in thirteen (13) articles published in the journal Biography between 1972 and 1979.
Yudhi Andoni, Febbrizal, Novi Yulia
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Embodied Healing Beyond Dualism: A Taiwanese Spiritual Group’s Take on Health and Disease
ReligionsModern healthcare systems, grounded in the logic of Western natural science, compartmentalize the mind and body, thereby privileging physical phenomena while excluding non-scientific or metaphysical understandings of illness.
Tien-Sheng Pan, Wei-Hsian Chi
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2017 Testimony被视为一个重要的知识来源。Testimony信念的确证是testimony知识论中的一个基本问题。对于这个问题,知识论学者们长期争论不休,主要分为还原论和非还原论两种主张,但这两种主张都面临难着以解决的困难。不过,近十年来出现了两个很有创见的新理论,即詹妮弗·拉基(Jennifer Lackey)和保罗·福克纳(Paul Faulkner)分别所提出的testimony信念确证的理论。这两个理论是对还原论和非还原论的片面性的超越,这是文章重点论述的。此外,针对这两种新理论 ...
孟峰
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source