Results 121 to 130 of about 7,040,880 (266)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The Debates Between Reductionism and Non-reductionism in Ethical Naturalism
, 2010 自然主义伦理学内部有还原论与非还原论两个派别。以哈曼为代表的还原论和以斯德津为代表的非还原论展开了持久的争论,针对道德性质的解释力、道德副现象论等问题进行辩驳。这两个流派都是自然主义伦理学中极为重要的分支,因此对双方理论的探讨有利于深化学界自然主义伦理学的研究。There are two schools in ethical naturalism: reductionism and non-reductionism.As each side’s representative respectively ...
杨松
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
, 2011 Reductionism is a philosophical notion that encompasses a set of ontological, methodological, and epistemological claims about how entities, processes, methods, and knowledge relate to one another across levels of organization and/or scientific domains ...
Malaterre, Christophe
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2017 Testimony被视为一个重要的知识来源。Testimony信念的确证是testimony知识论中的一个基本问题。对于这个问题,知识论学者们长期争论不休,主要分为还原论和非还原论两种主张,但这两种主张都面临难着以解决的困难。不过,近十年来出现了两个很有创见的新理论,即詹妮弗·拉基(Jennifer Lackey)和保罗·福克纳(Paul Faulkner)分别所提出的testimony信念确证的理论。这两个理论是对还原论和非还原论的片面性的超越,这是文章重点论述的。此外,针对这两种新理论 ...
孟峰
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Adaptive speciation: The role of natural selection in mechanisms of geographic and non-geographic speciation [PDF]
, 2005 Recent discussion of mechanism has suggested new approaches to several issues in the philosophy of science, including theory structure, causal explanation, and reductionism. Here, I apply what I take to be the fruits of the "new mechanical philosophy" to
Byron (formerly Baker), Jason M.
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source