Results 81 to 90 of about 10,367,564 (257)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An investigation into mental illness and its comorbidities from the perspective of supervenience physicalism

Philosophy, Ethics, and Humanities in Medicine
The exploration into the origin of human spirituality has always been a hot spot with many unsolved questions in the philosophy of mind, and issues concerning mental illness and its comorbidities are still unclear.
Ping Yang, Xinyue Zhang, Hongwen Song, Xiaochu Zhang   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

About "the less” and design

Convergências - Revista de Investigação e Ensino das Artes
Building on the Mies van Der Rohe slogan "less is more", the present research aims to identify phenomena and lines of thought that relate in different ways to a conceptual link between the idea of "less" and design.
Francesca La Rocca
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Reductionism and library and information science philosophy

, 2008
Purpose: The purpose of this article is to consider the meaning of 'reductionism' within the context of renewed efforts to make library and information science philosophy. Design/methodology/approach: This article argues that the question of reductionism,
Bonna Jones (19117708)
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Quantum Fundamentalism or Emergence? A Reply to Harris

Zygon
Mark Harris has developed a new research program at the intersection of theology and quantum physics, centered on two coordinated commitments: quantum fundamentalism, the claim that quantum mechanics has a unique standing within the sciences, and ...
doaj   +2 more sources

Religious Belief, Evidentialism, and Skeptical Theism

Cuestiones Teológicas, 2016
The purpose of the article is to develop a line of argument in favor of a religious belief in the existence of God, in such a way that it is possible to hold that: i) it is a rational belief and ii) it is non-dependent on contingent evidence.
Rafael Felipe Miranda Rojas
doaj  

Upholding Dignitas Personae in the Human Gene Editing Debate

Religions
This essay offers a philosophical and bioethical upholding of Dignitas Personae §27, which cautions against the use of human gene editing (HGE) for non-therapeutic purposes.
Maria Antonietta Castaldi, Fabio Gragnano   +1 more
doaj   +1 more source