Results 131 to 140 of about 10,385,388 (284)

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, EarlyView.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

Exploring the biosynthesis potential of permafrost microbiomes

Environmental Microbiome
Background Permafrost microbiomes are of paramount importance for the biogeochemistry of high latitude soils and while endemic biosynthetic domain sequences involved in secondary metabolism have been found in polar surface soils, the biosynthetic ...
Aileen Ute Geers, Yannick Buijs, Morten Dencker Schostag, Bo Elberling, Mikkel Bentzon-Tilia   +4 more
doaj   +1 more source

Prospection for potential new non-ribosomal peptide gene clusters in Bacillus genus isolated from fermented foods and soil through genome mining

Frontiers in Microbiology
Experimental studies, though often very costly, lead to the discovery of known antimicrobial products. Yet, pathogenic microorganisms are proving increasingly resistant to pre-existing antimicrobial molecules, and this is a cause for worldwide concern ...
Blaise Waongo, Libère Ndayishimiye, François Tapsoba, Wend-Soo Abel Zongo, Jinquan Li, Aly Savadogo   +5 more
doaj   +1 more source

Insights into Streptomyces spp. isolated from the rhizospheric soil of Panax notoginseng: isolation, antimicrobial activity and biosynthetic potential for polyketides and non-ribosomal peptides. [PDF]

BMC Microbiol, 2020
Peng F, Zhang MY, Hou SY, Chen J, Wu YY, Zhang YX.   +5 more
europepmc   +1 more source

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +2 more sources

Bacillus velezensis Bac-9, isolated from kefir, possesses antifungal activity and improves resistance of tomato plant against whitefly Bemisia tabaci

BMC Microbiology
Background The Bacillus genus comprises spore-forming, Gram-positive bacteria widely recognized for their capacity to produce bioactive compounds with antimicrobial properties.
Ernesto Pérez-Rueda, Ana Roblero-Aguilar, Carlos López-González, Denisse Domínguez-García, Ángel Herrera-Gorocica, Esaú Ruiz-Sánchez, Gabriel Lizama-Uc, Silvia Tenorio-Salgado   +7 more
doaj   +1 more source

Ribosomal Synthesis of Peptides with Multiple β‑Amino Acids

, 2016
The compatibility of β-amino acids with ribosomal translation was studied for decades, but it has been still unclear whether the ribosome can accept various β-amino acids, and whether the ribosome can introduce multiple β-amino acids in a peptide. In the
Yuki Goto (251586), Hiroshi Murakami (227877), Hiroaki Suga (295809), Tomoshige Fujino (1403092)   +3 more
core   +1 more source

Nosocomial Bacteria Inhibition with Polymyxin B: In Silico Gene Mining and In Vitro Analysis

Antibiotics
Multidrug-resistant bacteria present a significant public health challenge; such pathogens exhibit reduced susceptibility to conventional antibiotics, limiting current treatment options.
Jayendra Chunduru, Nicholas LaRoe, Jeremy Garza, Abdul N. Hamood, Paul W. Paré   +4 more
doaj   +1 more source

Antimicrobial metabolites produced by the plant growth-promoting rhizobacteria (PGPR): Bacillus and Pseudomonas

Advanced Agrochem
Plant growth-promoting rhizobacteria (PGPR) such as Bacillus and Pseudomonas have drawn broad attention and interest due to their agricultural benefits.
Yiheng Wang, Yongfu Pei, Xin Wang, Xiongfeng Dai, Manlu Zhu   +4 more
doaj   +1 more source

Cell-penetrating peptides for siRNA delivery to glioblastomas

, 2018
Delivery of small interfering RNA (siRNA) to suppress glioblastoma growth is a hurdle due to the critical obstacles of the blood-brain barrier and the siRNA properties of such as high negative charges and instability in serum.
Kim, Kumjee,, Maria Arvanitidou, Kumjee Kim, Hällbrink, Mattias,, Mattias Hällbrink, Ülo Langel, Artita Srimanee, Langel, Ülo,, Srimanee, Artita,, Arvanitidou, Maria,   +9 more
core   +1 more source