Results 181 to 190 of about 10,385,388 (284)

Algorithms for automatic annotation of Non Ribosomal Peptides

, 2016
La composition monomérique de polymères joue un rôle essentiel dans la comparaison de structures et dans la biologie de synthèse. Cependant, la plupart des ressources moléculaires en ligne donne accès à la structure atomique des molécules et non à leur structure monomérique.
openaire   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Real-time search-assisted multiplexed quantitative proteomics reveals system-wide cryptic translation initiation in human cancer cells. [PDF]

Genome Biol
Kozuka-Hata H, Hiroki T, Kitamura A, Miyamura N, Akiyama T, Inoue JI, Tsumoto K, Oyama M.   +7 more
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source

Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction. [PDF]

J Biol Chem
Mir Hassani Z, Goulet F, Nguyen DT, Landry-Voyer AM, Kwiatek L, Gaudet S, Boudreault PL, Azad T, Bachand F.   +8 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Mapping the architecture of protein complexes in <i>Arabidopsis</i> using cross-linking mass spectrometry. [PDF]

Proc Natl Acad Sci U S A
Trinh CS, Shrestha R, Mao P, Conner WC, Reyes AV, Karunadasa SS, Yu A, Liu G, Hu K, Xu SL.   +9 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Ubiquitination of the ribosomal-like domain of UBIQUITIN6 contributes to cell wall stress responses in Arabidopsis. [PDF]

Plant Cell
Zhu Y, Ramírez Rodríguez EA, Chow F, Azad FT, McNally U, Kang HS, Ebert B, McFarlane HE.   +7 more
europepmc   +1 more source