Results 81 to 90 of about 7,255,024 (307)

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

Quantitative study of interactions between Saccharomyces cerevisiae and Oenococcus oeni strains [PDF]

, 2008
This study examines the interactions that occur between Saccharomyces cerevisiae and Oenococcus oeni strains during the process of winemaking. Various yeast/bacteria pairs were studied by applying a sequential fermentation strategy which simulated the ...
Florence Mathieu, Mathieu, Florence, Nehme, Nancy, Taillandier, Patricia, Patricia Taillandier, Nancy Nehme   +5 more
core   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

With Advantages and Disadvantages The Role of Non-Saccharomyces Yeast In The Wine Industry

Turkish Journal of Food and Agriculture Sciences, 2022
This article aims to describe non-Saccharomyces yeast and their effects on wine composition, fermentation, chemistry and organoleptic characters. The use of non-Saccharomyces yeast is on the rise in the wine industry despite the negative perception from previous research.
openaire   +2 more sources

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Regulation of sporulation in the yeast Saccharomyces cerevisiae. [PDF]

, 2010
Sporulation of the budding yeast Saccharomyces cerevisiae — equivalent to gametogenesis in higher organisms, is a complex differentiation program induced by starvation of cells for nitrogen and carbon.
Rytka, Joanna, Bozenna Rempola, Rempola, Bozenna, Joanna Rytka, Piekarska, Iga, Iga Piekarska   +5 more
core  

Screening of enzymatic activities within different enological non-Saccharomyces yeasts

, 2017
Ninety-seven non-Saccharomyces wine yeast strains belonging to ten different genera and species (Candida spp. and Criptococcus spp.; Debaryomyces hansenii, Lachancea thermotolerans, Metschnikowia pulcherrima, Pichia kluyveri, Sporidiobolus salmonicolor ...
López-Alfaro, I. [0000-0002-6438-423X], Pilar Santamaría, López, R., Escribano, R. [0000-0002-5792-9457], López Martín, Rosa, Garijo, P. [0000-0003-0268-9414], Berlanas, Carmen, Gutiérrez, A.R. [0000-0002-2585-0576], Berlanas, C. [0000-0003-1930-6272], López Alfaro, Isabel, Carmen Berlanas, Patrocinio Garijo, González-Arenzana, L. [0000-0001-5181-3173], Gutiérrez, Ana Rosa, Escribano-Viana, Rocío, Ana Rosa Gutiérrez, González-Arenzana, L., Lucía González-Arenzana, Rosa López, Garijo, P., Santamaría, P., Santamaría, Pilar, Isabel López-Alfaro, Rocío Escribano   +23 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Effect of Saccharomyces, Non-Saccharomyces Yeasts and Malolactic Fermentation Strategies on Fermentation Kinetics and Flavor of Shiraz Wines

Fermentation, 2017
The use of non-Saccharomyces yeasts to improve complexity and diversify wine style is increasing; however, the interactions between non-Saccharomyces yeasts and lactic acid bacteria (LAB) have not received much attention.
Heinrich du Plessis, Maret du Toit, Hélène Nieuwoudt, Marieta van der Rijst, Martin Kidd, Neil Jolly   +5 more
doaj   +1 more source