Results 1 to 10 of about 385 (111)
Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [PDF]
EBioMedicine, 2016 Background: Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in ...
Mike L.T. Berendsen +3 more
doaj +7 more sources
Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19 [PDF]
Human Vaccines & Immunotherapeutics, 2021 No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction ...
Pouria Mosaddeghi +4 more
doaj +3 more sources
Non-specific effects of vaccinations in high-income settings: How to address the issue? [PDF]
Human Vaccines & Immunotherapeutics, 2018 “Non-specific effects” of vaccines go beyond the specific protective effects against the targeted diseases. They, if real, could theoretically be beneficial, neutral or negative. This article intends to answer the following questions: Do the non-specific
Alberto Donzelli +2 more
doaj +4 more sources
Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations [PDF]
Frontiers in Immunology, 2018 Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these ...
Deeva Uthayakumar +9 more
doaj +4 more sources
Australia, immunisation, GAVI, and the non‐specific effects of vaccines [PDF]
Australian and New Zealand Journal of Public Health, 2012 Frank Shann
doaj +4 more sources
The Yin and Yang of the Non-Specific Effects of Vaccines [PDF]
EBioMedicine, 2017 Stephen Cose
doaj +5 more sources
Non-specific effects of vaccination [PDF]
BMJ, 2005 EDITOR—I support Fine's plea that we review the optimal immunisation schedule in developing countries using evidence from controlled trials rather than observational data.1 There are almost no controlled trials of the effect on mortality from all causes for any of the vaccines in the World Health Organization's schedule. Fine …
Christine Stabell Benn +3 more
+13 more sources
The non-specific and sex-differential effects of vaccines [PDF]
Nature Reviews Immunology, 2020 The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also ...
Sabra L. Klein +9 more
openaire +5 more sources
EClinicalMedicine, 2021 Background: West African studies have suggested that national immunisation campaigns with oral polio vaccine (C-OPV) may non-specifically reduce all-cause child mortality rate by 15–25%.
Sebastian Nielsen +4 more
doaj +1 more source
Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines [PDF]
Drug Safety, 2023 The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against the vaccine-specific disease, may also have "non-specific effects" affecting the risk of unrelated diseases.
Christine Stabell Benn +15 more
openaire +7 more sources