The Yin and Yang of the Non-Specific Effects of Vaccines [PDF]
EBioMedicine, 2017 Stephen Cose
doaj +12 more sources
Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [PDF]
EBioMedicine, 2016 Background: Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in ...
Mike L.T. Berendsen +3 more
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Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations [PDF]
Frontiers in Immunology, 2018 Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these ...
Deeva Uthayakumar +9 more
doaj +6 more sources
Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19 [PDF]
Human Vaccines & Immunotherapeutics, 2021 No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction ...
Pouria Mosaddeghi +4 more
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Randomized clinical trials of COVID-19 vaccines: Do adenovirus-vector vaccines have beneficial non-specific effects? [PDF]
iScience, 2023 Summary: We examined the possible non-specific effects of novel mRNA- and adenovirus-vector COVID-19 vaccines by reviewing the randomized control trials (RCTs) of mRNA and adenovirus-vector COVID-19 vaccines. We calculated mortality risk ratios (RRs) for
Christine S. Benn +4 more
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Sex-differential non-specific effects of adjuvanted and non-adjuvanted rabies vaccines versus placebo on all-cause mortality in dogs (NERVE-Dog study): a study protocol for a randomized controlled trial with a nested case–control study [PDF]
BMC Veterinary Research, 2022 Background It has been proposed that childhood vaccines in high-mortality populations may have substantial impacts on mortality rates that are not explained by the prevention of targeted diseases, nor conversely by typical expected adverse reactions to ...
Darryn L. Knobel +10 more
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Non-specific effects of rabies vaccine on the incidence of common infectious disease episodes: study protocol for a randomized controlled trial [PDF]
Trials, 2020 Background Vaccines may cause non-specific effects (NSEs) on morbidity and mortality through immune-mediated mechanisms that are not explained by the prevention of the targeted disease.
Darryn Knobel +7 more
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Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children [PDF]
BMJ OpenObjectives Growing evidence suggests that vaccines targeting respiratory pathogens have non-specific and broader effects. We aimed to investigate the non-specific effects of respiratory vaccines on acute lower respiratory infection (ALRI ...
Leo Ng +5 more
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Do childhood vaccines have non-specific effects on mortality? [PDF]
, 2003 A recent article by Kristensen et al. suggested that measles vaccine and bacille Calmette–Guérin (BCG) vaccine might\ud reduce mortality beyond what is expected simply from protection against measles and tuberculosis.
O. William Cooper +3 more
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Letter to the editor RE: Berendsen et al., 2016 'Non-specific Effects of Vaccines and Stunting: Timing May Be Essential'. [PDF]
EBioMedicine, 2021 Ould Setti M, Ould Setti M.
europepmc +2 more sources