Results 31 to 40 of about 385 (111)

Non‐specific effects of vaccination on child survival? A prospective study in Senegal [PDF]

Tropical Medicine & International Health, 2005
SummaryObjectives  Several studies have shown an association between vaccination and child mortality in developing countries. The present paper examines this issue using data from a Senegalese rural area which has been monitored from 1983 to the present.Methods  We analysed two birth cohorts, comprising 7796 and 3573 persons who had received either BCG
Elguero, Eric, Simondon, Kirsten, Vaugelade, Jacques, Marra, Adama, Simondon, François   +4 more
openaire   +4 more sources

Unravelling the nature of non-specific effects of vaccines—A challenge for innate immunologists [PDF]

Seminars in Immunology, 2016
Epidemiological observations have shown that vaccines can influence morbidity and mortality more than can be ascribed to target-disease immunity. A growing number of immunological studies have helped identify possible biological mechanisms to explain these so-called nonspecific effects (NSE) of vaccines, including heterologous T-cell reactivity and ...
Christine Stabell Benn, Reinout van Crevel, Kristoffer Jarlov Jensen, Kristoffer Jarlov Jensen   +3 more
openaire   +3 more sources

Non-specific effects of rabies vaccine on the incidence of common infectious disease episodes: study protocol for a randomized controlled trial

Trials, 2020
Background Vaccines may cause non-specific effects (NSEs) on morbidity and mortality through immune-mediated mechanisms that are not explained by the prevention of the targeted disease.
Darryn Knobel, Christianah Ibironke Odita, Anne Conan, Donna Barry, Marshalette Smith-Anthony, Juliet Battice, Shianne England, Bradford D. Gessner   +7 more
doaj   +1 more source

Non-specific effects of vaccines: Current evidence and potential implications

Seminars in Immunology, 2018
Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations
de Bree, L.C.J., Koeken, V.A.C.M., Joosten, L.A.B., Joosten, L.A.B., Aaby, P., Benn, C.S., van Crevel, R., van Crevel, R., Netea, M.G., Netea, M.G.   +9 more
openaire   +6 more sources

Implications of the non-specific effect induced by Bacillus Calmette-Guerin (BCG) vaccine on vaccine recommendations

Jornal de Pediatria, 2023
Since the beginning of its use for the prevention of tuberculosis (TB) in 1921, other uses of BCG (Bacillus Calmette-Guérin) have been proposed, particularly in the treatment of malignant solid tumors, multiple sclerosis, and other autoimmune diseases.
Ekaterini Goudouris, Carolina Sanchez Aranda, Dirceu Solé   +2 more
openaire   +3 more sources

Potential role of specific antibodies as important vaccine induced protective mechanism against Aeromonas salmonicida in rainbow trout. [PDF]

PLoS ONE, 2012
Furunculosis caused by infection with Aeromonas salmonicida subsp. salmonicida has been a known threat to aquaculture for more than a century. Efficient prophylactic approaches against this disease are essential for continued growth of salmonid ...
Kasper Rømer Villumsen, Inger Dalsgaard, Lars Holten-Andersen, Martin Kristian Raida   +3 more
doaj   +1 more source

Specific and non-specific effects of Mycobacterium bovis BCG vaccination in dairy calves

Frontiers in Veterinary Science, 2023
Bovine tuberculosis (bTB) is a chronic disease mainly caused by Mycobacterium bovis, a zoonotic pathogen with economic significance as it leads to reduced milk and meat production, and high costs for control measures. The Bacillus Calmette-Guérin (BCG) vaccine, primarily used to prevent tuberculosis in humans, has also been studied for controlling bTB.
Catalina Contreras, Raúl Alegría-Moran, Mario Duchens, Pedro Ábalos, Renata López, Patricio Retamal   +5 more
openaire   +3 more sources

Non-specific effects of Pneumococcal and Haemophilus vaccines in children aged 5 years and under: a systematic review

BMJ Open, 2023
Objective To determine the evidence for non-specific effects of the Pneumococcal and Haemophilus influenza vaccine in children aged 5 years and under.Data sources A key word literature search of MEDLINE, EMBASE, The Cochrane Central Register of ...
Liam Glynn, Chris Watson, Joe Gallagher, Keith Geraghty, Mark T Ledwidge, Darragh Rooney   +5 more
doaj   +1 more source

Non-specific effects of vaccines: plausible and potentially important, but implications uncertain [PDF]

Archives of Disease in Childhood, 2017
Non-specific effects (NSE) or heterologous effects of vaccines are proposed to explain observations in some studies that certain vaccines have an impact beyond the direct protection against infection with the specific pathogen for which the vaccines were designed. The importance and implications of such effects remain controversial.
Andrew J Pollard, Adam Finn, Nigel Curtis   +2 more
openaire   +4 more sources

Implementation and assessment of vaccination programmes: the importance of vaccination sequence for overall health outcomes

Human Vaccines & Immunotherapeutics, 2018
In addition to their effect on the target infections, accumulating evidence indicates that vaccines have non-specific effects. Live measles vaccine (MV) has beneficial NSEs reducing mortality by more than can be explained by preventing measles infection.
Ane Bærent Fisker, Sanne Marie Thysen
doaj   +1 more source