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Identification of Compound‐B, a novel anti‐dengue virus agent targeting the non‐structural protein 4A

Antiviral Research, 2018
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever/dengue shock syndrome. At present, no antiviral drugs are available for treatment DENV infections.
Haruaki Nobori +6 more
semanticscholar +1 more source

Trans-complementation of HCV replication by non-structural protein 5A

Virus Research, 2006
Although establishment of the subgenomic replicon system has considerably facilitated genetic analysis of HCV replication, many details remain largely unknown. To initially test whether HCV replication could be affected in trans, complementation studies were conducted in which defective replicon RNAs carrying a luciferase reporter were introduced into ...
Xiao, Tong, Bruce A, Malcolm
openaire +2 more sources

Structural and functional comparison of the non-structural protein 4B in flaviviridae

Journal of Molecular Graphics and Modelling, 2007
Flaviviridae are evolutionarily related viruses, comprising the hepatitis C virus (HCV), with the non-structural protein 4B (NS4B) as one of the least characterized proteins. NS4B is located in the endoplasmic reticulum membrane and is assumed to be a multifunctional protein. However, detailed structure information is missing. The hydrophobic nature of
Welsch, C. +8 more
openaire +3 more sources

Automatic and sensitive detection of West Nile virus non-structural protein 1 with a portable SERS–LFIA detector