Results 1 to 10 of about 70 (68)

The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection [PDF]

International Journal of Molecular Sciences, 2020
Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it according to the World Health Organization (WHO). Influenza viruses belong to the Orthomyxoviridae family
Rui M M Brito, Nicia Rosário-Ferreira, Melo R   +2 more
exaly   +4 more sources

Zika Virus Non-Structural Protein 1 Antigen-Capture Immunoassay [PDF]

Viruses, 2021
Infection with Zika virus (ZIKV), a member of the Flavivirus genus of the Flaviviridae family, typically results in mild self-limited illness, but severe neurological disease occurs in a limited subset of patients. In contrast, serious outcomes commonly occur in pregnancy that affect the developing fetus, including microcephaly and other major birth ...
Brandon J. Beddingfield, Jessica N. Hartnett, Russell B. Wilson, Peter C. Kulakosky, Kristian G. Andersen, Refugio Robles-Sikisaka, Nathan D. Grubaugh, Argelia Aybar, Maria-Zunilla Nunez, Cesar D. Fermin, Robert F. Garry   +10 more
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Molecular Evolution of the Influenza A Virus Non-structural Protein 1 in Interspecies Transmission and Adaptation [PDF]

Frontiers in Microbiology, 2021
The non-structural protein 1 (NS1) of influenza A viruses plays important roles in viral fitness and in the process of interspecies adaptation. It is one of the most polymorphic and mutation-tolerant proteins of the influenza A genome, but its evolutionary patterns in different host species and the selective pressures that underlie them are hard to ...
Danyel Evseev, Katharine E. Magor
openaire   +3 more sources

Relative contribution of non-structural protein 1 in dengue pathogenesis [PDF]

, 2020
Abstract Dengue is a major public health concern in the tropical and sub-tropical world with no effective treatment. The controversial live attenuated virus vaccine Dengvaxia has boosted the pursuit of sub-unit vaccine approaches, and the non-structural protein 1 (NS1) has recently emerged as a promising candidate ...
Lee, Pei Xuan, Ting, Donald Heng Rong, Boey, Clement Peng Hee, Tan, Eunice Tze Xin, Chia, Janice Zuo Hui, Ong, Li Ching, Chua, Yen Leong, Hapuarachchi, Chanditha, Ng, Lee Ching, Alonso, Sylvie   +9 more
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Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis [PDF]

Virology Journal, 2012
Abstract Background Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments. BTV mRNAs are synthesised by the viral RNA-dependent RNA polymerase (RdRp) as exact plus sense copies of the genome segments.
Boyce Mark, Celma Cristina C P, Roy Polly   +2 more
openaire   +4 more sources

Structure and Function of the Influenza A Virus Non-Structural Protein 1

Journal of Microbiology and Biotechnology, 2019
The influenza A virus is a highly infectious respiratory pathogen that sickens many people with respiratory disease annually. To prevent outbreaks of this viral infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed.
Chang Woo, Han, Mi Suk, Jeong, Se Bok, Jang   +2 more
openaire   +3 more sources

Development of a Dengue Virus Serotype-Specific Non-Structural Protein 1 Capture Immunochromatography Method [PDF]

Sensors, 2021
Four serotypes of dengue virus (DENV), type 1 to 4 (DENV-1 to DENV-4), exhibit approximately 25–40% of the difference in the encoded amino acid residues of viral proteins. Reverse transcription of RNA extracted from specimens followed by PCR amplification is the current standard method of DENV serotype determination.
Poltep, K, Nakayama, EE, Sasaki, T, Kurosu, T, Takashima, Y, Phadungsombat, J, Kosoltanapiwat, N, Hanboonkunupakarn, B, Suwanpakdee, S, Imad, HA, Srimark, N, Kitamura, C, Yamanaka, A, Okubo, A, Shioda, T, Leaungwutiwong, P   +15 more
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The dengue virus non-structural 1 protein: Risks and benefits

Virus Research, 2014
The dengue virus (DENV) non-structural 1 (NS1) protein plays a critical role in viral RNA replication and has a central position in DENV pathogenesis. DENV NS1 is a glycoprotein expressed in infected mammalian cells as soluble monomers that dimerize in the lumen of the endoplasmic reticulum; NS1 is subsequently transported to the cell surface, where it
Jaime Henrique, Amorim, Rúbens Prince dos Santos, Alves, Silvia Beatriz, Boscardin, Luís Carlos de Souza, Ferreira   +3 more
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Association of dengue virus non-structural-1 protein with disease severity: a brief review

Transactions of The Royal Society of Tropical Medicine and Hygiene, 2022
AbstractDengue virus (DENV) was discovered by P. M. Ashburn and Charles F. Craig in 1907. Evidence of dengue-like illness was observed before 1907 and DENV epidemics have been reported from different parts of the world since then, with increased morbidity rates every year.
Charmi Ghetia, Puneet Bhatt, Chiranjay Mukhopadhyay   +2 more
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Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

PLoS ONE, 2010
Type I interferons (IFNs) function as the first line of defense against viral infections by modulating cell growth, establishing an antiviral state and influencing the activation of various immune cells. Viruses such as influenza have developed mechanisms to evade this defense mechanism and during infection with influenza A viruses, the non-structural ...
Baker, DP, Jia, D, Chan, RWY, Lee, SMY, Nicholls, JM, Wang, BX, Rahbar, R, Malik Peiris, JS, Chan, MCW, Fish, EN, Sun, B   +10 more
openaire   +6 more sources