Results 41 to 50 of about 42,828,722 (241)

The Scottish Structural Proteomics Facility : targets, methods and outputs [PDF]

, 2010
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined.
Garrett, Roger A., Barton, Geoffrey J, Mark Dorward (10196177), Prangishvili, D, Muse Oke (452182), Schwarz-Linek, Ulrich, Xu Peng, Melina Kerou (6987863), Catherine H Botting (16216415), James H Naismith (16216433), Prangishvili, D. A., Prakash Patel (594463), David T F Dryden (16216421), Johannes van Niekerk, C. A., C A Johannes van Niekerk (16216409), Carter, Lester G., Taylor, Garry L, Md Arif Sheikh (16216349), Dorward, M, Michal Zawadzki, McMahon, Stephen A., Sheikh, Md Arif, Kerou, Melina, Challis, GL, Muse Oke, Carter, LG, Weikart, Nadine D., James H. Naismith, Oke, M, Challis, Gregory L, McMahon, Stephen A, Yan, X, Malcolm F. White, Xuan Yan (4844139), Liu, Huanting, Melina Kerou, Weikart, Nadine D, van Niekerk, CA, Peter J. Coote, Botting, Catherine H., Michal Zawadzki (11327080), Taylor, GL, David T. F. Dryden, Nadia Kadi (2425486), Prangishvili, David, Sheikh, Md. Arif, Naismith, JH, Schwarz-Linek, Uli, Yan, Xuan, Ulrich Schwarz-Linek, Kadi, N, Coote, Peter J., White, MF, Stephen A. McMahon, Weikart, ND, Carter, Lester G, Kenneth A Johnson (16216388), White, Malcolm F., Overton, IM, Garrett, Roger A, Schmelz, Stefan, Mark Dorward, Kadi, Nadia, Nadia Kadi, Naismith, James H., Liu, H, Garry L Taylor (16216352), Dryden, DT, McMahon, SA, Xuan Yan, Coote, PJ, Niekerk, C. A. Johannes, Lester G. Carter, Zawadzki, M, Overton, Ian M.; id_orcid, Gregory L. Challis, Geoffrey J Barton (16216424), Gregory L Challis (16216427), Ian M Overton (16216406), White, Malcolm F, Lester G Carter (16208402), Stephen A McMahon (16216391), van Niekerk, C A Johannes, Dryden, David T F, Falconer, Helen, Cozens, Christopher, Patel, Prakash, Geoffrey J. Barton, Md. Arif Sheikh, Peng, X, Botting, Catherine H, Barton, Geoffrey J; id_orcid, Roger A Garrett (16216412), Ulrich Schwarz-Linek (5801099), Johnson, KA, Falconer, H, Dorward, Mark, Barton, Geoffrey J., Xu Peng (365714), Huanting Liu (3691537), Peng, Xu, Sheikh, MA, Oke, Muse, Powers, H, Helen Falconer, Nadine D. Weikart, Dryden, David T. F., Prakash Patel, Powers, Helen, Naismith, James H, Malcolm F White (16216430), Kenneth A. Johnson, Taylor, Garry L., Overton, Ian M., Schmelz, S, Catherine H. Botting, Helen Falconer (16216400), Coote, Peter J, Johnson, Kenneth A, Botting, CH, Stefan Schmelz, Kerou, M, Barton, GJ, David Prangishvili (22095), Johnson, Kenneth A., Zawadzki, Michal, Christopher Cozens, David Prangishvili, Nadine D Weikart (16216394), C. A. Johannes van Niekerk, Overton, Ian M, Christopher Cozens (5232944), Garrett, Roger Antony, Peter J Coote (16216418), Challis, Gregory L., Ian M. Overton, Roger A. Garrett, Garrett, RA, Cozens, C, Garry L. Taylor, Helen Powers (16216403), Stefan Schmelz (16216397), Helen Powers, Huanting Liu, Patel, P   +144 more
core   +1 more source

Identification of host proteins that interact with non-structural proteins-1α and -1β of PRRSV-1

Access Microbiology, 2019
Porcine reproductive and respiratory syndrome viruses (PRRSV) are responsible for the most important infectious disease affecting the global pig industry, causing respiratory disease in piglets and reproductive failure in sows. Both species of PRRSV (PRRSV-1 and −2) are rapidly evolving and existing vaccines are failing to control the PRRS panzootic ...
Sofia Riccio, Ben Jackson, Julian Hiscox, Simon Graham, Julian Seago   +4 more
openaire   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]

, 2009
To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core   +1 more source

Intracellular localization and effects of individually expressed human parechovirus 1 non-structural proteins

Journal of General Virology, 2007
Human parechovirus 1 (HPEV-1) has many unique features compared with other picornaviruses and it has been shown that the replication complex formed during HPEV-1 infection is different from that of other picornaviruses. Here, the intracellular localization and functional effects of individually expressed HPEV-1 non-structural proteins were studied. The
Camilla, Krogerus, Olga, Samuilova, Tuija, Pöyry, Eija, Jokitalo, Timo, Hyypiä   +4 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The rinderpest virus non-structural C protein blocks the induction of type 1 interferon

Virology, 2009
The innate immune response, in particular the production of type 1 interferons, is an essential part of the mammalian host response to viral infection. We have previously shown that rinderpest virus, a morbillivirus closely related to the human pathogen measles virus, blocks the actions of type 1 and type 2 interferons. We show here that this virus can
Boxer, Emma L., Nanda, Sambit K., Baron, Michael D.   +2 more
openaire   +2 more sources