Results 11 to 20 of about 42,828,722 (241)

False-positive dengue non-structural protein 1 in pregnancy [PDF]

Transactions of The Royal Society of Tropical Medicine and Hygiene
Abstract Dengue is a vector-borne infection, which contributes to significant morbidity and mortality in endemic areas. It manifests rapidly within 2 wk from febrile, critical to recovery phase. The point-of-care test (POCT) comprises the non-structural protein 1 (NS1) antigen, IgM and IgG, which aids rapid diagnosis, leading to timely ...
Tonnii Sia, Tze-cheng Wong, Yee-chiing Ong   +2 more
openaire   +3 more sources

Characterization of Gene Expression Suppression by Bovine Coronavirus Non-Structural Protein 1 [PDF]

Viruses
Coronavirus non-structural protein 1 (nsp1) is a pathogenic determinant of Betacoronaviruses. Previous studies demonstrated that the nsp1 of various coronaviruses induces host shutoff through a variety of mechanisms; however, there is little information on the function of bovine coronavirus (BCoV) nsp1. We aimed to characterize the host gene expression
Takehiro Ohkami, Ichika Kitashin, Riko Kawashima, Aimi Yoshida, Taizo Saito, Yasuhiro Takashima, Wataru Kamitani, Keisuke Nakagawa   +7 more
openaire   +4 more sources

The role of intrinsically disordered regions of SARS-CoV-2 nucleocapsid and non-structural protein 1 proteins [PDF]

Frontiers in Chemistry
Virus survival inside the host cell depends on the intricate mechanisms that recruit proteins involved in the arms race. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) proteome exhibits important levels of structural order. However, some of the SARS-CoV-2 proteins, such as the Nucleocapsid (N) and Non-structural protein 1 (Nsp1), contain ...
Getasew Shitaye, Getasew Shitaye, Nataliia Ventserova, Gianluca D’Abrosca, Martina Dragone, Eunice Wairimu Maina, Roberto Fattorusso, Rosa Iacovino, Luigi Russo, Carla Isernia, Carla Isernia, Gaetano Malgieri, Gaetano Malgieri   +12 more
openaire   +4 more sources

Coatomer protein complex I is required for efficient secretion of dengue virus non-structural protein 1 [PDF]

Journal of Virology
ABSTRACT Secreted non-structural protein 1 (sNS1) is an important orthoflavivirus pathogenic factor that can induce vascular leakage; a key symptom of severe dengue disease. Given the role of sNS1 in dengue pathogenesis, defining the molecular mechanisms of NS1 secretion may contribute towards development of NS1-targeting antiviral ...
Stephen M. Johnson, Siena M. Centofanti, Gustavo Bracho, Michael R. Beard, Jillian M. Carr, Nicholas S. Eyre   +5 more
openaire   +3 more sources

Altering Intracellular Localization of the RNA Interference Factors by Influenza A Virus Non-structural Protein 1 [PDF]

Frontiers in Microbiology, 2020
Influenza A virus (IAV) causes seasonal infections and periodic pandemics in humans. The non-structural protein 1 (NS1) of IAV is the main viral antagonist of the innate immune responses that play a key role in influenza pathogenesis. However, the mechanism to disrupt the host cell homeostasis by IAV NS1 remains poorly understood.
Wang, Hua, Tian, Zhonghui, Xu, Yan, Wang, Qi, Ding, Shou-Wei, Li, Yang   +5 more
openaire   +6 more sources

A computational approach for rational discovery of inhibitors for non-structural protein 1 of SARS-CoV-2 [PDF]

Computers in Biology and Medicine, 2021
Non-structural protein 1 (Nsp1), a virulence agent of SARS-CoV-2, has emerged as an important target for drug discovery. Nsp1 shuts down the host gene function by associating with the 40S ribosomal subunit.Molecular interactions, drug-likeness, physiochemical property predictions, and robust molecular dynamics (MD) simulations were employed to discover
Rahul Singh, Vijay Kumar Bhardwaj, Pralay Das, Rituraj Purohit   +3 more
openaire   +4 more sources

Multi-class protein fold classification using a new ensemble machine learning approach. [PDF]

, 2003
Protein structure classification represents an important process in understanding the associations between sequence and structure as well as possible functional and evolutionary relationships.
Deville, Y, Gilbert, D, Tan, A
core   +6 more sources

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F., Palmarini, M., Ratinier Maxime, Ratinier, Maxime, Golder, Matthew, Nunes, S.F., Alessia Armezzani, Sandro Filipe Nunes, Kathryn Allan, Allan Kathryn, Allan, K., Rixon, Frazer, Golder, M., Allan, Kathryn, Nunes Sandro Filipe, Frazer Rixon, Bayoumy, Amr, Shaw, A., Matthew Golder, Franzoni, G., Caporale Marco, Giulia Franzoni, Golder Matthew, Nunes, Sandro Filipe, Bayoumy Amr, Shaw, Andrew, Amr Bayoumy, Palmarini Massimo, Armezzani, A., Shaw Andrew, Palmarini, Massimo, Ratinier, M., Armezzani, Alessia, Franzoni Giulia, Franzoni, Giulia, Maxime Ratinier, Andrew Shaw, Rixon Frazer, Marco Caporale, Massimo Palmarini, Armezzani Alessia, Bayoumy, A., Caporale, Marco, Caporale, M.   +43 more
core   +1 more source

Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein [PDF]

, 2012
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral ...
Krause Kurt L., Luckner, Sylvia R., Krause, Kurt L., Luckner Sylvia R., Lambden, Paul R., Sylvia R Luckner, Kurt L Krause, Clarke, Ian N., Paul R Lambden, Baker, Estelle S., Ian N Clarke, Baker Estelle S., Estelle S Baker, Ward Vernon K., Lambden Paul R., Ward, Vernon K., Clarke Ian N., Vernon K Ward   +17 more
core   +1 more source

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target [PDF]

, 2010
Nonribosomal peptide synthetases (NRPSs) are large multimodular and multidomain enzymes that are involved in synthesising an array of molecules that are important in human and animal health.
Lee, TV, Arcus, VL, Lott, JS, Johnson, RD, Lott, J. Shaun, Vickery L. Arcus, Johnson, Richard D., Arcus, Vickery L., J. Shaun Lott, Richard D. Johnson, T. Verne Lee, Lee, T. Verne   +11 more
core   +1 more source