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Design of peptide inhibitors for influenza a non-structural protein 1

2016
Influenza A is responsible for tens of thousands of annual fatalities in the United States. The conventional medical strategy relies on prevention of infection using vaccines where are mildly effective at best and require yearly updates to reflect the expected prevalent strains, and anti-viral drugs for which there is significant clinical resistance ...
openaire   +1 more source

The effect of the dengue non-structural 1 protein expression over the HepG2 cell proteins in a proteomic approach

Journal of Proteomics, 2017
Dengue is an important mosquito borne viral disease in the world. Dengue virus (DENV) encodes a polyprotein, which is cleaved in ten proteins, including the non-structural protein 1 (NS1). In this work, we analyzed the effect of NS1 expression in one hepatic cell line, HepG2, through a shotgun proteomic approach.
Kíssila, Rabelo   +8 more
openaire   +2 more sources

[Expression of non-structural protein 1 of Bombyx mori densovirus-3].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2009
We cloned the NS1 gene of BmDNV-3 into the prokaryotic expression vector pET-30a after we amplified the NS1 gene by PCR, and then we transformed the pET-30a-NS1 plasmid into BL21 star to express BmDNV-3 NS1. After we induced NS1 expression by IPTG, we used Western blot analysis to indentify the recombinant protein, the result indicated that the ...
Wei, Yu   +5 more
openaire   +1 more source

Variability among the neuraminidase, non-structural 1 and PB1-F2 proteins in the influenza A virus genome

Virus Genes, 2012
Influenza A viruses infect a large number of mammals and birds resulting in sporadic infections, seasonal epidemics, epizootics and pandemics. The segmented genome of the virus encodes 10 or 11 proteins depending on the strain. The neuraminidase, non-structural 1 and the PB1-F2 proteins are known to be variable in their length due to very specific ...
openaire   +2 more sources

[Research progress in the structure and function of dengue virus non-structural 1 protein].

Bing du xue bao = Chinese journal of virology, 2015
Dengue virus (DENV) is a re-emerging disease transmitted by the Aedes mosquitoes and has become a major public health problem in southern China. Currently, no antiviral drug or effective vaccine exist to control this disease. The chimeric DENV structural protein vaccine cannot elicit balanced levels of protective immunity to each of the four viral ...
Yue, Chen, Rui-wen, Ren, Jian-wei, Liu
openaire   +1 more source

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

IScience, 2020
Dene Littler   +2 more
exaly  

Interactome3D: adding structural details to protein networks

Nature Methods, 2013
Arnaud Ceol   +2 more
exaly  

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