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Investigation into heptatitis C non-structural protein 3 and its role in hepatocellular carcinoma
, 2007 openaire +1 more source
Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target [PDF]
Journal of Biological Chemistry, 2010 Hepatitis C virus non-structural protein 3 contains a serine protease and an RNA helicase. Protease cleaves the genome-encoded polyprotein and inactivates cellular proteins required for innate immunity. Protease has emerged as an important target for the development of antiviral therapeutics, but drug resistance has turned out to be an obstacle in the ...
Kevin D Raney +2 more
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Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection
Archives of Virology, 2021Although dengue virus (DENV) replication occurs in the cytoplasm, the nucleus plays an essential role during infection. Both the capsid protein (C) and non-structural protein 5 (NS5) are translocated into the infected cell nucleus to favor viral replication.
Selvin Noé Palacios-Rápalo +6 more
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Refolding of the full-length non-structural protein 3 of hepatitis C virus
Protein Expression and Purification, 2005An easy and reproducible procedure for purification and refolding of the full-length non-structural protein 3 (NS3) from hepatitis C virus has been developed. Refolding was achieved by simply diluting the protein into a suitable buffer. Low protein concentration, high pH, highly reducing conditions, the presence of detergent, and low viscosity were ...
Anton, Poliakov, U Helena, Danielson
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Current Pharmaceutical Biotechnology, 2014
Dengue infections produce a distinct character of virus-induced intracellular membrane alterations which are associated with the viral replication machinery. Currently, the NS3 protein is being targeted for antiviral therapy against dengue. NS3 protein of dengue virus interacts with nuclear receptor binding protein (NRBP) of human causing cell ...
Pratap, Parida +2 more
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Dengue infections produce a distinct character of virus-induced intracellular membrane alterations which are associated with the viral replication machinery. Currently, the NS3 protein is being targeted for antiviral therapy against dengue. NS3 protein of dengue virus interacts with nuclear receptor binding protein (NRBP) of human causing cell ...
Pratap, Parida +2 more
openaire +2 more sources