Results 251 to 260 of about 1,374,243 (286)
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A coiled-coil motif in non-structural protein 3 (NS3) of bluetongue virus forms an oligomer
Virus Genes, 2015Bluetongue, an arthropod-borne non-contagious hemorrhagic disease of small ruminants, is caused by bluetongue virus (BTV). Several structural and non-structural proteins encoded by BTV have been associated with virulence mechanisms. In the present study, the NS3 protein sequences of bluetongue viral serotypes were analyzed for the presence of heptad ...
Nirmal, Chacko +7 more
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Journal of Clinical Virology, 1999
Chronic hepatitis resulting from the hepatitis C virus (HCV) infection leads to cirrhosis in at least half the infected patients and increases the risk of hepatocellular carcinoma. There are indications that this pathogenic effect may result from the disturbance of intracellular signal cascades caused by the interaction with viral antigens.
P, Borowski +4 more
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Chronic hepatitis resulting from the hepatitis C virus (HCV) infection leads to cirrhosis in at least half the infected patients and increases the risk of hepatocellular carcinoma. There are indications that this pathogenic effect may result from the disturbance of intracellular signal cascades caused by the interaction with viral antigens.
P, Borowski +4 more
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Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded
Biochemical and Biophysical Research Communications, 2009Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is involved both in the viral replication and particle production. Its third domain (NS5A-D3), although not absolutely required for replication, is a key determinant for the production and assembly of novel HCV particles.
Hanoulle, Xavier +5 more
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Peptidic Inhibitors of the Hepatitis C Virus Serine Protease within Non- Structural Protein 3
Current Pharmaceutical Design, 2002New treatments for HCV (Hepatitis C virus) infections are likely to arise from inhibition of the essential, virally-encoded enzymes. These targets include the serine protease required for processing of the HCV polyprotein. The protease constitutes one functional domain of the bifunctional HCV NS3 (non-structural protein 3). Here, insights regarding the
T O, Fischmann, P C, Weber
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[Expression of non-structural protein 1 of Bombyx mori densovirus-3].
Wei sheng wu xue bao = Acta microbiologica Sinica, 2009We cloned the NS1 gene of BmDNV-3 into the prokaryotic expression vector pET-30a after we amplified the NS1 gene by PCR, and then we transformed the pET-30a-NS1 plasmid into BL21 star to express BmDNV-3 NS1. After we induced NS1 expression by IPTG, we used Western blot analysis to indentify the recombinant protein, the result indicated that the ...
Wei, Yu +5 more
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Hybridoma, 2008
Dengue fever and dengue hemorrhagic fever/dengue shock syndrome are highly infectious diseases caused by dengue virus (DV). DV non-structural protein 3 (NS3) is known to possess ATPase, helicase, and protease activity that is a constitutive part of the replication complex of DV. In this study, we discuss the cloning, expression, and purification of the
Zongtao, Chen +3 more
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Dengue fever and dengue hemorrhagic fever/dengue shock syndrome are highly infectious diseases caused by dengue virus (DV). DV non-structural protein 3 (NS3) is known to possess ATPase, helicase, and protease activity that is a constitutive part of the replication complex of DV. In this study, we discuss the cloning, expression, and purification of the
Zongtao, Chen +3 more
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XAS Characterization of the Zn Site of Non-structural Protein 3 (NS3) from Hepatitis C Virus
AIP Conference Proceedings, 2007XANES spectra of non structural protein 3 (NS3) have been calculated using 4 Zn coordination models from three crystallographic structures in the Protein Data Base (PDB): 1DY9, subunit B, 1CU1 subunit A and B, and 1JXP subunit B. Results indicate that XANES is an appropriate tool to distinguish among them. Experimental XANES spectra have been simulated
I. Ascone +3 more
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Functionally distinct T-Cell epitopes within the hepatitis C virus non-structural 3 protein
Human Immunology, 1999Clearance of Hepatitis C Virus (HCV) infection is an uncommon phenomenon. To understand the mechanism of viral persistence despite active cellular and humoral responses, we examined the in vitro cytokine response of PBMC from an HCV sero-positive, asymptomatic individual to recombinant intact antigen and sixty-nine overlapping peptides of the HCV non ...
N M, Tabatabai +5 more
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Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production
Gut, 2011Background The non-structural (NS) 3/4A protease/helicase of the hepatitis C virus is known to modulate signalling pathways in the infected hepatocyte by cleaving CARD adaptor inducing IFNβ (Cardif), T-cell protein tyrosine phosphatase (TC-PTP) and TIR domain-containing adaptor inducing IFNβ (TRIF), but the effects ...
Erwin Daniel, Brenndörfer +6 more
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Zeitschrift für Kristallographie, 2010
We present preliminary structural results of the non-structural protein 3 (nsP3) macro domain from the Mayaro virus (MAYV), an emerging virus of South American tropic regions, by means of synchrotron X-ray powder diffraction. Indexing of the diffraction patterns indicate a trigonal/hexagonal lattice (a = 61.60 A, c = 94.61 A), analogous to the known ...
Nicolas Papageorgiou +9 more
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We present preliminary structural results of the non-structural protein 3 (nsP3) macro domain from the Mayaro virus (MAYV), an emerging virus of South American tropic regions, by means of synchrotron X-ray powder diffraction. Indexing of the diffraction patterns indicate a trigonal/hexagonal lattice (a = 61.60 A, c = 94.61 A), analogous to the known ...
Nicolas Papageorgiou +9 more
openaire +1 more source