Results 261 to 270 of about 1,374,243 (286)

Construction and characterization of an intracellular single-chain human antibody to hepatitis C virus non-structural 3 protein

Journal of Hepatology, 2002
We developed a single-chain antibody fragment (scFv) to the non-structural 3 protein (NS3) of hepatitis C virus (HCV) and tested its ability to interfere with the HCV replication cycle in infected hepatocytes.The variable regions of the human monoclonal antibody CM3.B6 that recognizes a conformational epitope within the helicase domain of NS3 were ...
Sullivan D.e., Curiel D.t., Krasnykh V., Mikheeva G., Gaglio P., Morri C.b., Dash S., Gerber M.a., MONDELLI, MARIO UMBERTO   +8 more
openaire   +2 more sources

FUNCTIONAL AND STRUCTURAL STUDIES OF THE PAPAIN-LIKE PROTEASE ENCODED IN CORONAVIRUS NON-STRUCTURAL PROTEIN 3

2023
Coronaviruses (CoVs) are single-stranded, positive-sense RNA viruses in the Coronaviridae family. Within this family are four different genera, Alpha-, Beta-, Gamma-, and Deltacoronaviruses with human-infecting CoVs spanning the Alpha- and Beta-CoV genera.
openaire   +1 more source

[Inducible expression of non-structural protein 3 of hepatitis C virus in E. coli].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2003
To express recombinant non-structural protein 3 of hepatitis C virus (HCV) in E. coli.The non-structural 3 (NS3) region DNA fragment of HCV was amplified by polymerase chain reaction (PCR) and inserted into inducible proeukaryotic expressive vector pET 30C(+)at Bam H1/EcoR1 sites.
Jun, Cheng, Yanwei, Zhong, Yan, Liu, Jing, Dong, Jizhen, Yang, Shouchun, Yang   +5 more
openaire   +1 more source

Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation

2012
Two decades after the discovery of the Hepatitis C Virus (HCV), Hepatitis C infection still persists to be a global health problem. With the recent approval of the first set of directly acting antivirals (DAAs), the rate of sustained viral response for HCV-infected patients increased significantly. However, a complete cure has not been found yet.
openaire   +2 more sources

A computational approach for rational discovery of inhibitors for non-structural protein 1 of SARS-CoV-2

Computers in Biology and Medicine, 2021
Rahul Singh, Vijay Kumar Bhardwaj, Pralay Das   +2 more
exaly  

[Expression of non-structural region 3 gene of the Chinese HGY and analysis of the antigenicity of the recombinant proteins].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2003
This study is to analyze the antigenicity of the NS3 proteins of Chinese HGV and their potential use in the serological diagnosis.All three gene fragments of NS3 region of Chinese HGV were cloned into the pRSET vectors to construct recombinant plasmids. In E.
G, Chen, S, Bi, M, Zhan
openaire   +1 more source

Identification of potential drugs against SARS-CoV-2 non-structural protein 1 (nsp1)

Journal of Biomolecular Structure and Dynamics, 2021
Gabriela De Lima Menezes, Roosevelt Alves da Silva   +1 more
exaly  

Comparative analysis of non structural protein 1 of SARS-CoV2 with SARS-CoV1 and MERS-CoV: An in silico study

Journal of Molecular Structure, 2021
Ankur Chaudhuri
exaly  

An in-silico evaluation of different bioactive molecules of tea for their inhibition potency against non structural protein-15 of SARS-CoV-2

Food Chemistry, 2021
Jatin Sharma, Vijay Kumar Bhardwaj, Rahul Singh   +2 more
exaly  

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

IScience, 2020
Dene R Littler, Benjamin S Gully, Jamie Rossjohn   +2 more
exaly