Results 51 to 60 of about 1,374,243 (286)

Research review on non-structural protein 3 (ns3) of classical swine fever virus and its potential applications in vaccine development [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Classical Swine Fever Virus (CSFV) is a virus that poses a serious threat to the pig farming industry, and its non-structural protein 3 (NS3) plays a key role in the virus"s replication, pathogenicity, and immune evasion.
Hai-Yang YU, Dong-Mei GAO, Jun ZHAO
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Modeling of tertiary and quaternary protein structures by homology [PDF]

, 2012
The structure of a protein is crucial to understand its function. Despite this importance, experimentally solved structures are only available for a small portion of the currently known protein sequences.
Kiefer, Florian
core   +1 more source

Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors

Molecules, 2019
Zika virus (ZIKV), one of the flaviviruses, has attracted worldwide attention since its large epidemics around Brazil. Association of ZIKV infection with microcephaly and neurological problems such as Guillain–Barré syndrome has prompted ...
Siyu Zhu, Chaozai Zhang, Lina S. Huang, Xing-Quan Zhang, Yan Xu, Xiong Fang, Jiao Zhou, Meixian Wu, Robert T. Schooley, Ziwei Huang, Jing An   +10 more
doaj   +1 more source

Similarity of the non-amyloid-β component and C-terminal tail of monomeric and tetrameric alpha-synuclein with 14-3-3 sigma

Computational and Structural Biotechnology Journal, 2021
Alpha-synuclein (αSyn) is often described as a predominantly disordered protein that has a propensity to self-assemble into toxic oligomers that are found in patients with Parkinson's and Alzheimer's diseases.
Sarah R. Evans, Colista West, Judith Klein-Seetharaman   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profiling

Frontiers in Virology
IntroductionChikungunya virus (CHIKV), an alphavirus transmitted by mosquitoes, has instigated several epidemics in recent years, sparking intensive efforts to understand its biology.
Priyanshu Srivastava, Nimisha Mishra, Sakshi Chaudhary, Sujatha Sunil   +3 more
doaj   +1 more source

Rift Valley Fever Virus Non-Structural Protein S Is Associated with Nuclear Translocation of Active Caspase-3 and Inclusion Body Formation

Viruses, 2022
Rift Valley fever phlebovirus (RVFV) causes Rift Valley fever (RVF), an emerging zoonotic disease that causes abortion storms and high mortality rates in young ruminants as well as severe or even lethal complications in a subset of human patients.
Lukas Mathias Michaely, Melanie Rissmann, Federico Armando, Felicitas von Arnim, Markus Keller, Martin Eiden, Rebecca König, Benjamin Gutjahr, Wolfgang Baumgärtner, Martin H. Groschup, Reiner Ulrich   +10 more
doaj   +1 more source