Results 41 to 50 of about 1,374,243 (286)

Characterization of amino acids in the Non‐Structural Protein 2B Hydrophilic domain required for efficient activation of the Flavivirus Non‐Structural 3 Protein Serine Protease

The FASEB Journal, 2007
West Nile virus (WNV) and dengue virus type 2 (DV2) are pathogens causing widespread disease for which there is no cure. These viruses encode a two‐component protease that is essential for polyprotein processing. Protease activation requires interaction between the nonstructural (NS) protein 3 and the NS2B.
Niklaus H Mueller, Andrea O’Neill, Erin D Reichert, Gina M Ganey, Nagarajan Pattabiraman, R. Padmanabhan   +5 more
openaire   +1 more source

Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]

, 2008
The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Menz, Beatrice, Schmid, Ralf, Burgert, Hans-Gerhard, Martina Sester, Hans-Gerhard Burgert, Sester, Martina, Koebernick, Katja, Beatrice Menz, Katja Koebernick, Ralf Schmid   +9 more
core   +1 more source

FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
Dallman Timothy J., Nussinov, R., Oliver C. Redfern, Christine A. Orengo, Sillitoe, I., Dessailly Benoît H., Orengo, C.A., Benoît H Dessailly, Redfern, OC, Timothy J. Dallman, Oliver C Redfern, Benoît H. Dessailly, Dallman, TJ, Dessailly, B.H., Orengo Christine A., Ian Sillitoe, Timothy J Dallman, Sillitoe, I, Redfern Oliver C., Christine A Orengo, Dallman, T.J., Sillitoe Ian, Dessailly, BH, Redfern, O.C., Orengo, CA   +24 more
core   +1 more source

The Scottish Structural Proteomics Facility : targets, methods and outputs [PDF]

, 2010
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined.
Garrett, Roger A., Barton, Geoffrey J, Mark Dorward (10196177), Prangishvili, D, Muse Oke (452182), Schwarz-Linek, Ulrich, Xu Peng, Melina Kerou (6987863), Catherine H Botting (16216415), James H Naismith (16216433), Prangishvili, D. A., Prakash Patel (594463), David T F Dryden (16216421), Johannes van Niekerk, C. A., C A Johannes van Niekerk (16216409), Carter, Lester G., Taylor, Garry L, Md Arif Sheikh (16216349), Dorward, M, Michal Zawadzki, McMahon, Stephen A., Sheikh, Md Arif, Kerou, Melina, Challis, GL, Muse Oke, Carter, LG, Weikart, Nadine D., James H. Naismith, Oke, M, Challis, Gregory L, McMahon, Stephen A, Yan, X, Malcolm F. White, Xuan Yan (4844139), Liu, Huanting, Melina Kerou, Weikart, Nadine D, van Niekerk, CA, Peter J. Coote, Botting, Catherine H., Michal Zawadzki (11327080), Taylor, GL, David T. F. Dryden, Nadia Kadi (2425486), Prangishvili, David, Sheikh, Md. Arif, Naismith, JH, Schwarz-Linek, Uli, Yan, Xuan, Ulrich Schwarz-Linek, Kadi, N, Coote, Peter J., White, MF, Stephen A. McMahon, Weikart, ND, Carter, Lester G, Kenneth A Johnson (16216388), White, Malcolm F., Overton, IM, Garrett, Roger A, Schmelz, Stefan, Mark Dorward, Kadi, Nadia, Nadia Kadi, Naismith, James H., Liu, H, Garry L Taylor (16216352), Dryden, DT, McMahon, SA, Xuan Yan, Coote, PJ, Niekerk, C. A. Johannes, Lester G. Carter, Zawadzki, M, Overton, Ian M.; id_orcid, Gregory L. Challis, Geoffrey J Barton (16216424), Gregory L Challis (16216427), Ian M Overton (16216406), White, Malcolm F, Lester G Carter (16208402), Stephen A McMahon (16216391), van Niekerk, C A Johannes, Dryden, David T F, Falconer, Helen, Cozens, Christopher, Patel, Prakash, Geoffrey J. Barton, Md. Arif Sheikh, Peng, X, Botting, Catherine H, Barton, Geoffrey J; id_orcid, Roger A Garrett (16216412), Ulrich Schwarz-Linek (5801099), Johnson, KA, Falconer, H, Dorward, Mark, Barton, Geoffrey J., Xu Peng (365714), Huanting Liu (3691537), Peng, Xu, Sheikh, MA, Oke, Muse, Powers, H, Helen Falconer, Nadine D. Weikart, Dryden, David T. F., Prakash Patel, Powers, Helen, Naismith, James H, Malcolm F White (16216430), Kenneth A. Johnson, Taylor, Garry L., Overton, Ian M., Schmelz, S, Catherine H. Botting, Helen Falconer (16216400), Coote, Peter J, Johnson, Kenneth A, Botting, CH, Stefan Schmelz, Kerou, M, Barton, GJ, David Prangishvili (22095), Johnson, Kenneth A., Zawadzki, Michal, Christopher Cozens, David Prangishvili, Nadine D Weikart (16216394), C. A. Johannes van Niekerk, Overton, Ian M, Christopher Cozens (5232944), Garrett, Roger Antony, Peter J Coote (16216418), Challis, Gregory L., Ian M. Overton, Roger A. Garrett, Garrett, RA, Cozens, C, Garry L. Taylor, Helen Powers (16216403), Stefan Schmelz (16216397), Helen Powers, Huanting Liu, Patel, P   +144 more
core   +1 more source

Fast and accurate genome-wide predictions and structural modeling of protein–protein interactions using Galaxy

BMC Bioinformatics, 2023
Background Protein–protein interactions play a crucial role in almost all cellular processes. Identifying interacting proteins reveals insight into living organisms and yields novel drug targets for disease treatment.
Aysam Guerler, Dannon Baker, Marius van den Beek, Bjoern Gruening, Dave Bouvier, Nate Coraor, Stephen D. Shank, Jordan D. Zehr, Michael C. Schatz, Anton Nekrutenko   +9 more
doaj   +1 more source

Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein

, 2012
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral ...
Krause Kurt L., Luckner, Sylvia R., Krause, Kurt L., Luckner Sylvia R., Lambden, Paul R., Sylvia R Luckner, Kurt L Krause, Clarke, Ian N., Paul R Lambden, Baker, Estelle S., Ian N Clarke, Baker Estelle S., Estelle S Baker, Ward Vernon K., Lambden Paul R., Ward, Vernon K., Clarke Ian N., Vernon K Ward   +17 more
core   +1 more source

Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein

Journal of General Virology, 1996
The immunogenicity and antigenicity of an enzymatically functional (ATPase/helicase) recombinant protein encompassing residues 1207-1612 of the hepatitis C virus (HCV) non-structural 3 (NS3) protein was characterized using B10 congenic mice. Previous studies have indicated a high frequency of NS3-specific antibodies in HCV-infected humans.
M, Sällberg, Z X, Zhang, M, Chen, L, Jin, A, Birkett, D L, Peterson, D R, Milich   +6 more
openaire   +2 more sources

An artificial immune system for clustering amino acids in the context of protein function classification [PDF]

, 2009
This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon, Clark, Edward, Flower, Darren R., Secker, Andrew D., Davies, Matthew N., Freitas, Alex A.   +5 more
core   +1 more source

Biophysical Characterization of Essential Phosphorylation at the Flexible C-Terminal Region of C-Raf with 14-3-3ζ Protein. [PDF]

PLoS ONE, 2015
Phosphorylation at the C-terminal flexible region of the C-Raf protein plays an important role in regulating its biological activity. Auto-phosphorylation at serine 621 (S621) in this region maintains C-Raf stability and activity.
Anirban Ghosh, Bhisma Narayan Ratha, Nilanjan Gayen, Kamal H Mroue, Rajiv K Kar, Atin K Mandal, Anirban Bhunia   +6 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source