Results 31 to 40 of about 1,374,243 (286)

Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N)

Majalah Obat Tradisional, 2022
Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV.
Roihatul Mutiah, Chamlah Ayatillah, Yen yen Ari Indrawijaya, Arief Suryadinata   +3 more
doaj   +1 more source

An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2

Computational and Structural Biotechnology Journal, 2021
There is an urgent need to develop effective treatments for coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Fangfang Yan, Feng Gao
doaj   +1 more source

Protein-Ligand Interactions: Docking, Design and Conformation Change [PDF]

, 2003
Virtual ligand screening has proven to be a successful strategy in drug design. An in house-developed procedure (HierDock), a coarse grain docking method followed by a fine grain search procedure, was used to determine the binding site for sugars in the
Datta, Deepshikha
core   +1 more source

Non‐Structural Protein 3 of Hepatitis C Virus Inhibits Phosphorylation Mediated by cAMP‐Dependent Protein Kinase [PDF]

European Journal of Biochemistry, 1996
Inspection of the amino acid sequence of the non‐structural region of the hepatitis C virus (HCV) gene product reveals a sequence of 14 amino acids, Arg1487‐Arg‐Gly‐Arg‐Thr‐Gly‐Arg‐Gly‐Arg‐Arg‐Gly‐Ile‐Tyr‐Arg1500, located in the non‐structural protein, NS3.
P, Borowski, M, Heiland, K, Oehlmann, B, Becker, L, Kornetzky, H, Feucht, R, Laufs   +6 more
openaire   +2 more sources

Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]

, 2009
To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core   +1 more source

The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated

Virology, 2010
To analyze the proteins interacting with the severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein, a SARS-CoV was engineered including two tags associated to the E protein. Using this virus, complexes of SARS-CoV E and other proteins were purified using a tandem affinity purification system.
Álvarez, Enrique, DeDiego, Marta L., Nieto-Torres, Jose L., Jiménez-Guardeño, Jose M., Marcos-Villar, Laura, Enjuanes, Luis   +5 more
openaire   +3 more sources

A DIVA system based on the detection of antibodies to non-structural protein 3 (NS3) of bluetongue virus

Veterinary Microbiology, 2009
Vaccination programs for the control of bluetongue (BT) in ruminants have limitations due to difficulties in differentiating infected from vaccinated animals (DIVA). To overcome this problem a DIVA test that looks at a differential immune response to bluetongue virus (BTV) non-structural protein 3 (NS3) was developed.
Barros, Sílvia C., Cruz, Benedita, Luís, Tiago M., Ramos, Fernanda, Fagulha, Teresa, Duarte, Margarida, Henriques, Margarida, Fevereiro, Miguel   +7 more
openaire   +2 more sources

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo   +23 more
core   +1 more source

Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis

Viruses, 2020
Venezuelan equine encephalitis virus (VEEV), a mosquito transmitted alphavirus of the Togaviridae family, can cause a highly inflammatory and encephalitic disease upon infection.
Allison Bakovic, Nishank Bhalla, Stephanie Kortchak, Chengqun Sun, Weidong Zhou, Aslaa Ahmed, Kenneth Risner, William B. Klimstra, Aarthi Narayanan   +8 more
doaj   +1 more source

Structural and biochemical characterization of non-structural protein 3 from flavivirus [PDF]

, 2019
Flaviviruses are positive sense RNA viruses transmitted by arthropods. The flavivirus genus includes many important human pathogens such as Dengue Virus (DENV), West Nile virus (WNV), Yellow fever Virus (YFV), and recently emerged Zika Virus (ZIKV). About 40% of the world population is at risk of the flavivirus infections.
openaire   +2 more sources