Results 21 to 30 of about 1,374,243 (286)

Integrative multi-omics landscape of non-structural protein 3 of severe acute respiratory syndrome coronaviruses [PDF]

Genomics Proteomics Bioinformatics, 2021
Abstract The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is currently a global pandemic. Extensive investigations have been performed to study the clinical and cellular effects of SARS-CoV-2 infection.
Shi R, Feng Z, Zhang X.
europepmc   +5 more sources

Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution [PDF]

Progress in Biophysics and Molecular Biology, 2019
Dengue- (DENV) and Zika viruses (ZIKV) rely on their non-structural protein 5 (NS5) including a methyl-transferase (MTase) and a RNA-dependent RNA polymerase (RdRp) for capping and synthesis of the viral RNA, and the non-structural protein 3 (NS3) with its protease and helicase domain for polyprotein possessing, unwinding dsRNA proceeding replication ...
Saw, Wuan Geok, Pan, Ankita, Manimekalai, Malathy Sony Subramanian, Grüber, Ardina, Grüber, Gerhard   +4 more
openaire   +3 more sources

In silico modeling of ligand molecule for non structural 3 (NS3) protein target of flaviviruses [PDF]

Bioinformation, 2012
Flaviviruses are small, enveloped RNA viruses which cause a variety of diseases into animals and man. Despite the existence of licensed vaccines, yellow fever, Japanese encephalitis and tick-borne encephalitis also claim many thousands of victims each year across their vast endemic areas.
Shefali, Agnihotri, Ranjana, Narula, Kaishiv, Joshi, Sandeep, Rana, Maneet, Singh   +4 more
openaire   +2 more sources

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential [PDF]

Open Biology, 2020
Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation.
Johannes Gregor Matthias Rack, Valentina Zorzini, Zihan Zhu, Marion Schuller, Dragana Ahel, Ivan Ahel   +5 more
doaj   +1 more source

Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]

, 2012
BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly, Boyce, Mark, Roy, Polly, Celma, Cristina CP, Cristina C P Celma, Boyce Mark, Mark Boyce, Polly Roy, Celma Cristina C P   +8 more
core   +1 more source

Phytochemicals from Bangladeshi Medicinal Plants Potentially Targeting Non-Structural Protein 2/Non-Structural Protein 3 Chimera of Dengue Virus: An in silico study

Dhaka University Journal of Pharmaceutical Sciences, 2022
In Bangladesh, the incidence and death rate of patients suffering from dengue infection are escalating. To date, there is no effective antiviral against dengue virus. Treatment regimen mostly includes symptomatic management of the disease. In this study, we performed molecular docking with 36 phytochemicals extracted from Bangladeshi medicinal plants ...
Niaz Morshed, Rumman Reza, Md Nazmus Samdani, Muhammad Asaduzzaman   +3 more
openaire   +1 more source

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F., Palmarini, M., Ratinier Maxime, Ratinier, Maxime, Golder, Matthew, Nunes, S.F., Alessia Armezzani, Sandro Filipe Nunes, Kathryn Allan, Allan Kathryn, Allan, K., Rixon, Frazer, Golder, M., Allan, Kathryn, Nunes Sandro Filipe, Frazer Rixon, Bayoumy, Amr, Shaw, A., Matthew Golder, Franzoni, G., Caporale Marco, Giulia Franzoni, Golder Matthew, Nunes, Sandro Filipe, Bayoumy Amr, Shaw, Andrew, Amr Bayoumy, Palmarini Massimo, Armezzani, A., Shaw Andrew, Palmarini, Massimo, Ratinier, M., Armezzani, Alessia, Franzoni Giulia, Franzoni, Giulia, Maxime Ratinier, Andrew Shaw, Rixon Frazer, Marco Caporale, Massimo Palmarini, Armezzani Alessia, Bayoumy, A., Caporale, Marco, Caporale, M.   +43 more
core   +1 more source

COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning

Frontiers in Immunology, 2020
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus,
Edison Ong, Mei U Wong, Anthony Huffman, Yongqun He, Yongqun He   +4 more
doaj   +1 more source

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome [PDF]

, 2007
The severe acute respiratory syndrome coronavirus (SARS-CoV) genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products.
Brunn, Albrecht von, Teepe, Carola, Caroline C Friedel, Ralph Baric, Haas, Jürgen, von Brunn, Albrecht, Simpson Jeremy C., Jeremy C. Simpson, Simpson, Jeremy C., Ralf Zimmer, Roberts, Rhonda, Carola Teepe, Rainer Pepperkok, Baric Ralph, Haas Jürgen, Simpson, Jeremy, Zimmer, Ralf, Zimmer Ralf, Caroline C. Friedel, Friedel, Caroline C., Haas, Juergen, Teepe Carola, Albrecht von Brunn, Rhonda Roberts, Jürgen Haas, Friedel Caroline C., Pepperkok Rainer, Pepperkok, Rainer, Roberts Rhonda, Baric, Ralph, Jeremy C Simpson, von Brunn Albrecht   +31 more
core   +1 more source

Non-Contiguous Protein Recombination [PDF]

, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source