Results 1 to 10 of about 1,374,243 (286)

Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2 [PDF]

Communications Biology, 2023
Reporting the crystal structure of the N-terminal domain of the viral nucleocapsid protein in complex with the ubiquitin-like domain 1 of Nsp3 in SARS-CoV ...
Xincheng Ni, Yinze Han, Renjie Zhou, Yanmei Zhou, Jian Lei   +4 more
doaj   +4 more sources

The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last [PDF]

Viruses, 2018
Alphaviruses encode 4 non-structural proteins (nsPs), most of which have well-understood functions in capping and membrane association (nsP1), polyprotein processing and RNA helicase activity (nsP2) and as RNA-dependent RNA polymerase (nsP4).
Benjamin Götte, Lifeng Liu, Gerald M. McInerney   +2 more
doaj   +5 more sources

Dengue virus non-structural protein 3 inhibits mitochondrial respiration by impairing complex I function [PDF]

mSphere
Dengue virus (DENV) infection is known to affect host cell metabolism, but the molecular players involved are still poorly known. Using a proteomics approach, we identified six DENV proteins associated with mitochondria isolated from infected hepatocytes,
Bruna G. Sousa, Nathane C. Mebus-Antunes, Lorena O. Fernandes-Siqueira, Marjolly B. Caruso, Georgia N. Saraiva, Clara F. Carvalho, Thais C. Neves-Martins, Antonio Galina, Russolina B. Zingali, Julianna D. Zeidler, Andrea T. Da Poian   +10 more
doaj   +4 more sources

Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells [PDF]

npj Viruses
Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2).
Tessy A. H. Hick, Taja Zotler, Davita Bosveld, Corinne Geertsema, Monique M. van Oers, Gorben P. Pijlman   +5 more
doaj   +5 more sources

O'nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3. [PDF]

PLoS Neglected Tropical Diseases, 2013
O'nyong nyong virus (ONNV) and Chikungunya virus (CHIKV) are two closely related alphaviruses with very different infection patterns in the mosquito, Anopheles gambiae.
Kali D Saxton-Shaw, Jeremy P Ledermann, Erin M Borland, Janae L Stovall, Eric C Mossel, Amber J Singh, Jeffrey Wilusz, Ann M Powers   +7 more
doaj   +5 more sources

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3 [PDF]

Viruses, 2021
Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus and a category B select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat VEEV exposure and resultant disease manifestations. The C-terminus of the VEEV
Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan   +5 more
doaj   +2 more sources

Non-Structural Protein 3 of Duck Tembusu Virus Induces Autophagy via the ERK and PI3K–AKT–mTOR Signaling Pathways [PDF]

Frontiers in Immunology, 2022
Despite autophagy’s pivotal role in the replication of viruses such as duck Tembusu virus (DTMUV), which has caused massive economic losses to the poultry industry in the world, the specific relationships between DTMUV and cellular autophagy remain ...
Jun Zhao, Tingting Zhang, Tingting Zhang, Guomin Chen, Ningwei Geng, Zhiyun Guo, Shengliang Cao, Yudong Yang, Kuihao Liu, Siqi Wang, Yiran Zhao, Fanliang Meng, Sidang Liu, Meijie Jiang, Ning Li, Ning Li   +15 more
doaj   +2 more sources

Research note: duck Tembusu virus non-structural protein 3 induced autophagy through endoplasmic reticulum stress [PDF]

Poultry Science
Duck Tembusu virus (DTMUV) causes severe infectious diseases in poultry. Previous studies have shown that DTMUV induced autophagy and endoplasmic reticulum stress (ERS) in host cells, thereby influencing the virus proliferation.
Shuna Zhang, Ji Fu, Liya Zhu, Yihao Lu, Zhaopeng Zhang, Luna Yu, Jianhua Qiu, Gang Wang, Ning Li   +8 more
doaj   +2 more sources

Genetic characterization of the non-structural protein-3 gene of bluetongue virus serotype-2 isolate from India [PDF]

Veterinary World, 2017
Aim: Sequence analysis and phylogenetic studies based on non-structural protein-3 (NS3) gene are important in understanding the evolution and epidemiology of bluetongue virus (BTV).
Raghavendra Sumanth Pudupakam, Shobana Raghunath, Meghanath Pudupakam, Sreenivasulu Daggupati   +3 more
doaj   +2 more sources

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins [PDF]

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +2 more sources