Results 151 to 160 of about 14,031,935 (298)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The influence of real-world factors on threat detection performance in airport X-ray screening

, 2008
The visual search task carried out by X-ray screening personnel has begun to be investigated in a number of recent experiments. The goal of the present thesis was, therefore, to extend previous examinations of the factors that may be detrimental to ...
Godwin, Hayward James
core   +1 more source

Suspect and non-target screening of contaminants of emerging concern in Norwegian biogas digestates

Environmental Chemistry and Ecotoxicology
To achieve a circular bioeconomy, nutrients within residues such as food waste (FW) and sewage sludge (SS) must be recycled to e.g., food production. However, these biowastes often contain numerous contaminants which are recycled alongside the nutrients.
Aasim M. Ali, Are Sæle Bruvold, Astrid S. Nesse, Charlotte L. Nakken, Roland Kallenborn, Monica Sanden, Christopher P. Higgins, Stig Valdersnes   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Comparative assessment of screening workflows for characterizing occupational exposure to chemicals in humans: an EU-PARC interlaboratory study

Environmental Sciences Europe
Biomonitoring of occupational exposure to mixtures of chemicals remains a major challenge, as conventional targeted approaches can only cover a limited number of compounds. Suspect and non-target screening (SS/NTS) using high-resolution mass spectrometry
Baninia Habchi, Aurélie Martin Remy, Lidia Belova, Adrian Covaci, Annelaure Damont, Tina Kosjek, Carolin Huber, Nathalie Grova, Guillaume Antoine, Tarek Moufawad, Eirini Baira, Christian Baudry, Clément Chalet, Riccardo De Santo, Gaud Dervilly, Radu Corneliu Duca, François Fenaille, Mariana F. Fernández, Catherine Gabriel, Corentin Huet, Gaëlle Jadé, Anna Laura Iamiceli, Ardiana Kajtazi, Olli Kärkkäinen, Konstantinos M. Kasiotis, Alkistis Kevrekidou, Štěpán Koudelka, Lucyna Kozlowska, Marja Lamoree, Michel Laurentie, Bruno Le Bizec, Rosalie Nijssen, Herbert Oberacher, Elliott J. Price, Helena Plešnik, Žan Rekar, Andrea Rodriguez-Carrillo, Dimosthenis Sarigiannis, Jean-Marie Savignac, Marta Stelmasiak, Katriina Sunnarborg, Aikaterini Termentzi, An Van Nieuwenhuyse, Romain Vuillaume, Emma L. Schymanski, Douglas N. Rutledge, Jean-Philippe Antignac, Sophie Ndaw   +47 more
doaj   +1 more source

Critical review on data processing algorithms in non-target screening: challenges and opportunities to improve result comparability. [PDF]

Anal Bioanal Chem, 2023
Renner G, Reuschenbach M.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

FindPFΔS: Non-Target Screening for PFAS─Comprehensive Data Mining for MS² Fragment Mass Differences. [PDF]

Anal Chem, 2022
Zweigle J, Bugsel B, Zwiener C.
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

From target analysis to suspect and non-target screening of endocrine-disrupting compounds in human urine. [PDF]

Anal Bioanal Chem, 2022
Musatadi M, Caballero C, Mijangos L, Prieto A, Olivares M, Zuloaga O.   +5 more
europepmc   +1 more source