Results 151 to 160 of about 1,616,230 (293)

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and nutrients from two constructed wetlands in a city of southeastern China

Heliyon
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a large class of toxic contaminants. Nutrients are closely related to the ecological health of aquatic systems. Both have received widespread global attention.
Shiyue Li, Zhen Zhao, Jing Liu, Boxuan Zhang, Baocang Han, Yuntao Ma, Limin Jin, Ningzheng Zhu, Guoping Gao, Tian Lin   +9 more
doaj   +1 more source

From target analysis to suspect and non-target screening of endocrine-disrupting compounds in human urine. [PDF]

Anal Bioanal Chem, 2022
Musatadi M, Caballero C, Mijangos L, Prieto A, Olivares M, Zuloaga O.   +5 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography–high resolution mass spectrometry

Environment International
Controlling and minimising background contamination is crucial for maintaining a high quality of samples in human biomonitoring targeting organic chemicals. We assessed the contamination of three previous types and one newly introduced medical-grade type
Martin Krauss, Carolin Huber, Tobias Schulze, Martina Bartel-Steinbach, Till Weber, Marike Kolossa-Gehring, Dominik Lermen   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pollution by polar pesticides and pharmaceuticals and risk assessment in surface water bodies along the French Mediterranean coast: Complementarity of target and non-target screenings

Environmental Chemistry and Ecotoxicology
Anthropogenic activities are the source of a wide range of organic micropollutants (OMPs) found in all water bodies. Among them, pharmaceuticals and pesticides are the most found in watercourses and their impacts on non-target organisms have already been
Nicolas Martin, Geoffroy Duporté, Etienne Lemaire, Andrés Sauvêtre, Marine Bertrand, David Rosain, Elena Gomez, Emilie Farcy   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Non-target Screening of Emerging Organic Pollutants in Siberian Sediments

, 2023
Til tross for sin avsidesliggende beliggenhet, er Arktis i økende grad truet av forurensning, særlig fra kjemisk avrenning. I lys av dette undersøker denne studien både målrettede og ikke-målrettede analytiske metoder, og anvender disse teknikkene for å evaluere sedimentprøver fra Sibirs kystlinje.
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source