Results 141 to 150 of about 1,616,230 (293)

A Non-targeted Proteomics Newborn Screening Platform for Inborn Errors of Immunity

Journal of Clinical Immunology
Abstract Purpose Newborn screening using dried blood spot (DBS) samples for the targeted measurement of metabolites and nucleic acids has made a substantial contribution to public healthcare by facilitating the detection of neonates with genetic disorders.
Hirofumi Shibata, Daisuke Nakajima, Ryo Konno, Atsushi Hijikata, Motoko Higashiguchi, Hiroshi Nihira, Saeko Shimodera, Takayuki Miyamoto, Masahiko Nishitani-Isa, Eitaro Hiejima, Kazushi Izawa, Junko Takita, Toshio Heike, Ken Okamura, Hidenori Ohnishi, Masataka Ishimura, Satoshi Okada, Motoi Yamashita, Tomohiro Morio, Hirokazu Kanegane, Kohsuke Imai, Yasuko Nakamura, Shigeaki Nonoyama, Toru Uchiyama, Masafumi Onodera, Ryuta Nishikomori, Osamu Ohara, Yusuke Kawashima, Takahiro Yasumi   +28 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Target and non-target screening for the existence, ecological risk and source analysis of contaminants of emerging concern (CECs) in groundwater

Environmental Chemistry and Ecotoxicology
Contaminants of emerging concern (CECs) are increasingly being discharged into the groundwater environment worldwide, causing a significant threat to human health and the environment.
Kai Liu, Jinrong Qiu, Chih-Huang Weng, Junshi Tao, Zhongen Tang, Jingwen Zeng, Na Liu, Xiujuan Wang   +7 more
doaj   +1 more source

Suspect and non-targeted screening of chemical pollutants in Botswana's aquatic environments

Emerging Contaminants
Chemical pollution in the aquatic systems of Botswana has been sparsely studied despite its potential ecological importance. Here, we perform a study of water samples collected from 13 locations distributed across Botswana to obtain the first overview of the nature and distribution of chemical contaminants across the country's aquatic environment. High
Kgato P. Selwe, Charlotte R. Head, Gothatamang N. Phokedi, Jens E.T. Andersen, J. Brett Sallach, Caroline E.H. Dessent   +5 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Critical review on data processing algorithms in non-target screening: challenges and opportunities to improve result comparability. [PDF]

Anal Bioanal Chem, 2023
Renner G, Reuschenbach M.
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Long non-coding RNA AC133552.2: biomarker and therapeutic target in osteosarcoma via PANoptosis gene screening

Scientific Reports
Osteosarcoma, the most common primary bone cancer in children and adolescents, presents significant challenges, particularly in metastasis and recurrence, resulting in poor survival rates.
Wenrui Zhao, Yameng Wang, Junchao Zhu, Shahrzad Arya, Guowen Huang, Shengqin Li, Qi Chen, Xijuan Liu, Jinghong Yuan, Jingyu Jia   +9 more
doaj   +1 more source

FindPFΔS: Non-Target Screening for PFAS─Comprehensive Data Mining for MS² Fragment Mass Differences. [PDF]

Anal Chem, 2022
Zweigle J, Bugsel B, Zwiener C.
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source