Results 121 to 130 of about 132,778 (287)

A new Korean nomenclature for steatotic liver disease [PDF]

Clinical and Molecular Hepatology
Nonalcoholic Fatty Liver Disease (NAFLD) Nomenclature Revision Consensus Task Force on behalf of the Korean Association for the Study of the Liver (KASL)
doaj   +3 more sources

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease [PDF]

, 2015
Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression.
Agostinelli, Laura, Alisi, Anna, Bruscalupi, Giovannella, Ceccarelli, Sara, Crudele, Annalisa, Cucchiara, Salvatore, De Stefanis, Cristiano, Furlanello, Cesare, Gnani, Daniela, Mina, Marco, Musso, Giovanni, Nobili, Valerio, Panera, Nadia, Petrini, Stefania, Rychlicki, Chiara, Stronati, Laura, Svegliati Baroni, Gianluca   +16 more
core   +2 more sources

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD.

PLoS ONE, 2018
Background and aimsNonalcoholic fatty liver disease is one of the major complications of obesity, occurring already in pediatric age. Insulin like growth factor-I has been proposed as a potential therapeutic agent for its beneficial effect in ...
Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati, Valerio Nobili, Stefano Cianfarani   +6 more
doaj   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Sex Hormone-Binding Globulin Levels Are Inversely Associated With Nonalcoholic Fatty Liver Disease in HIV-Infected and -Uninfected Men. [PDF]

, 2019
BackgroundNonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease worldwide. Elevated sex hormone-binding globulin (SHBG) levels have been observed in the setting of HIV and may protect against some metabolic disorders.
Brown, Todd T, Budoff, Matthew J, Kingsley, Lawrence A, Lake, Jordan E, Palella, Frank J, Post, Wendy S, Price, Jennifer C, Seaberg, Eric C, Thio, Chloe L, Wang, Ruibin, Witt, Mallory D   +10 more
core  

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

The Role of Omega-3 Fatty Acids on the Prevention and Treatment of Nonalcoholic Fatty Liver Disease: A Review of Published Papers

مجله دانشکده پزشکی اصفهان, 2014
Background: 10 to 35% of the adult population all round the world is infected with nonalcoholic fatty liver disease (NAFLD). So far, no cure is recommended for this disease.
Hamid Zolfaghari, Kourosh Jafarian, Bijhan Iraj, Gholamreza Askari   +3 more
doaj  

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source