Results 141 to 150 of about 5,865,913 (286)

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Association Between Locomotive Syndrome and Metabolic Dysfunction‐Associated Steatotic Liver Disease in a Health Examination Cohort: A Cross‐Sectional Study

Hepatology Research, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is associated with liver fat and other health problems. In this study of 7776 adults who underwent health examinations, early mobility impairment was more common in individuals with MASLD.
Shinya Yokoyama, Takanori Ito, Taku Tanaka, Hiroaki Hiraiwa, Takashi Honda, Yoji Ishizu, Norihiro Imai, Kenta Yamamoto, Kazuki Sahara, Tetsuhito Kojima, Naoyoshi Kariya, Hiroki Kawashima   +11 more
wiley   +1 more source

The association between non–high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease in non-obese individuals: A cross-sectional study

Journal of International Medical Research
Objective This study aimed to investigate the association between the non–high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease in non-obese individuals, using data from the National ...
Shengyi Zhu, Wen Ding, Xiaowei Rui, Yanwen Yao, Linhua Yao   +4 more
doaj   +1 more source

Hepatic steatosis risk in nonobese Chinese adults with type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) may be an important comorbidity in nonobese Chinese adults with type 1 diabetes (T1D). We assessed the likelihood of hepatic steatosis using the hepatic steatosis index (HSI) in 47 nonobese Chinese adults with T1D (mean age 46.9 ± 14.1 years; BMI 22.6 ± 2.5 kg/m2) and examined ...
Zehua Jin, Jianhua Ma, Yuanyang Zhao, Yi Luo, Christopher K Rayner, Tongzhi Wu, Yong Luo   +6 more
wiley   +1 more source

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, EarlyView.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source