Results 41 to 50 of about 78,820 (216)
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang +9 more
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Role of nonalcoholic fatty liver disease in hepatocellular carcinoma
Annals of Hepatology, 2009 Obesity and related disorders are a common cause of morbidity worldwide. Nonalcoholic fatty liver disease is the most important hepatic consequence of adipose accumulation.
Norberto C. Chávez-Tapia +2 more
doaj +1 more source
Nonalcoholic Fatty Liver Disease-Related Chronic Kidney Disease
Canadian Journal of Gastroenterology and Hepatology, 2020 Nonalcoholic fatty liver disease has become the main concern of hepatologists around the world and the main research topic for identifying effective and safe therapy.
Camelia Cojocariu +9 more
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Advanced Science, EarlyView.Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan +19 more
wiley +1 more source
The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Lipids in Health and Disease, 2010 Nonalcoholic fatty liver disease is increasingly regarded as a hepatic manifestation of metabolic syndrome, and the severity of nonalcoholic fatty liver disease seems to increase in parallel with other features of metabolic syndrome.
Bengmark Stig, Liu Qing, Qu Shen
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The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Evaluation of liver stiffness measurement–based scores in liver transplantation recipients
Liver Transplantation, EarlyView., 2022 Abstract Combining bioclinical parameters with liver stiffness measurement (LSM) has improved the diagnostic performance of vibration‐controlled transient elastography (VCTE) for detection of advanced fibrosis in patients with chronic liver disease. However, this approach has not yet been tested in liver transplantation (LT) recipients.
Tamoore Arshad +11 more
wiley +1 more source
Acta Médica PortuguesaIntroduction: Nonalcoholic fatty liver disease is the leading cause of pediatric chronic liver disease. Although nonalcoholic fatty liver disease is closely associated with obesity, its relationship with metabolic syndrome in children is not fully ...
Sofia Ferreira +4 more
doaj +1 more source
Advanced Science, EarlyView.ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang +8 more
wiley +1 more source
ASSOCIATION OF ANTHROPOMETRIC AND BIOCHEMICAL PARAMETERS WITH NONALCOHOLIC FATTY LVER DISEASE
Pakistan Armed Forces Medical Journal, 2019 Objective: To study the association of anthropometric and biochemical parameters with nonalcoholic fatty liver disease (NAFLD) diagnosed on ultrasonography (USG). Study Design: Cross sectional analytical study.
Muhammad Usman Munir +3 more
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