Results 61 to 70 of about 78,820 (216)

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice

ChemMedChem, EarlyView.
A low‐toxicity bioactive composition of oxidovanadium(IV) and exopolysaccharide levan is synthesized, characterized, and shown to reduce hyperglycemia, hypertriglyceridemia, and TyG index in a mice model of dexamethasone‐induced insulin resistance. Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more ...
Amanda K. J. P. F. da Silva, Eucilene K. de L. B. Marques, Lidiane M. A. de Lima, Widarlane A. S. Alves, Dayane A. Gomes, Pedro L. Guzzo, Mônica F. Belian, Wagner E. Silva, Eduardo C. Lira   +8 more
wiley   +1 more source

Nonalcoholic fatty liver disease

Journal of Lipid Research, 2009
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and, indeed, worldwide. It has become a global public health issue.
Sandra K. Erickson
doaj   +1 more source

Fluorescent Dyes for Probing Intracellular and Subcellular Polarity

Chemistry–Methods, EarlyView.
Fluorescent probes are crucial tools for measuring cellular microenvironment polarity, a parameter that influences physiological organelle function and diseases such as cancer. This text details the probes' physicochemical principles, intracellular targeting strategies, and key photophysical parameters for polarity estimation.
M. Carmen Gonzalez‐Garcia, Maria J. Ruedas‐Rama, Juan A. González‐Vera, Emilio Garcia‐Fernandez, Angel Orte   +4 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Effect of Vitamin D Supplement on Nonalcoholic Fatty Liver: A Systematic Review on Randomized Clinical Trials

تحقیقات نظام سلامت, 2020
Background: Fatty liver is a common metabolic disorder that results in abnormal liver function due to the excessive accumulation of fat in the liver cells. Vitamin D can play a role in the improvement of fatty liver symptoms due to its anti-inflammatory,
فاطمه سادات میریعقوبى, مهران نوری, غلامرضا عسکری   +2 more
doaj  

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population.

PLoS ONE, 2019
AIMS:The relationship between nonalcoholic fatty liver disease and incident metabolic syndrome in metabolically healthy subjects is unknown. We aimed to investigate whether nonalcoholic fatty liver disease is a predictor of future metabolic syndrome in ...
Seokhun Yang, Soongu Kwak, Jeong-Hoon Lee, Shinae Kang, Seung-Pyo Lee   +4 more
doaj   +1 more source

Nonalcoholic fatty liver disease

Annals of Hepatology, 2004
Nonalcoholic fatty liver disease is a clinicopathologic syndrome that encompasses several clinical entities. The spectrum of conditions ranges from simple steatosis to steatohepatitis, fibrosis and end stage liver disease.
Lafaine M. Grant, Mauricio Lisker-Melman
doaj   +1 more source

Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism

Food Bioengineering, EarlyView.
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing, Shanshan Deng, Mengyao Zhao, Liming Zhao   +3 more
wiley   +1 more source

Postoperative association between impaired renal function and vascular dysfunction in liver transplant recipients

, 2022
Liver Transplantation, EarlyView.
Domenico A. Chavez, Marie‐Claire Evans, Natalie J. Bohmke, Hiba Kamal, Loan Quynh Tran, Chandra Bhati, Susan Wolver, Mohammad S. Siddiqui, Danielle L. Kirkman   +8 more
wiley   +1 more source